Date published: 2025-12-10

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ARP-1 Inhibitors

ARP-1 inhibitors represent a class of chemical compounds that specifically target and modulate the activity of ARP-1 (Apoptosis Repressor with a CARD domain). ARP-1, also known as NLR family CARD domain-containing protein 3 (NLRC3), is a member of the nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family, which plays a crucial role in the regulation of immune responses and inflammation. As an intracellular sensor, ARP-1 is involved in the modulation of immune signaling pathways, particularly those associated with the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and type I interferon pathways. These pathways are critical in mediating responses to various stimuli, including microbial infections and cellular stress. The inhibition of ARP-1, therefore, influences the downstream signaling cascades that are essential for maintaining immune homeostasis and modulating inflammatory responses. The design and synthesis of ARP-1 inhibitors involve intricate chemical engineering, with a focus on achieving high specificity and affinity for the ARP-1 protein. These inhibitors often consist of complex organic molecules that are capable of interacting with the CARD domain of ARP-1, disrupting its ability to oligomerize or interact with other signaling molecules. Structural biology techniques, such as X-ray crystallography and nuclear magnetic resonance (NMR) spectroscopy, are commonly employed to elucidate the binding interactions between ARP-1 inhibitors and their target, facilitating the rational design of more potent inhibitors. The development of ARP-1 inhibitors also involves extensive computational modeling and molecular docking studies to predict the binding affinity and optimize the chemical structure for improved selectivity. These compounds serve as valuable tools in the study of ARP-1's role in cellular processes and offer insights into the broader functions of NLR proteins in immune regulation.

Items 1 to 10 of 11 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Bortezomib

179324-69-7sc-217785
sc-217785A
2.5 mg
25 mg
$132.00
$1064.00
115
(2)

Bortezomib is a proteasome inhibitor that directly impacts ARP-1 by inhibiting proteasomal degradation. ARP-1, being a substrate of the proteasome, undergoes degradation, and Bortezomib disrupts this process, leading to increased ARP-1 levels.

MG-132 [Z-Leu- Leu-Leu-CHO]

133407-82-6sc-201270
sc-201270A
sc-201270B
5 mg
25 mg
100 mg
$56.00
$260.00
$980.00
163
(3)

MG-132, another proteasome inhibitor, acts similarly to Bortezomib by preventing the degradation of ARP-1 through proteasomal inhibition. By stabilizing ARP-1 levels, MG-132 indirectly influences cellular processes where ARP-1 plays a role.

Carfilzomib

868540-17-4sc-396755
5 mg
$40.00
(0)

Carfilzomib, a selective proteasome inhibitor, directly targets ARP-1 by preventing its degradation via the proteasome. The accumulation of ARP-1 induced by Carfilzomib can modulate cellular processes where ARP-1 is involved.

Geldanamycin

30562-34-6sc-200617B
sc-200617C
sc-200617
sc-200617A
100 µg
500 µg
1 mg
5 mg
$38.00
$58.00
$102.00
$202.00
8
(1)

Geldanamycin is an Hsp90 inhibitor that indirectly influences ARP-1 stability. ARP-1 is known to interact with Hsp90, and Geldanamycin disrupts this interaction, leading to ARP-1 degradation. The modulation of ARP-1 levels by Geldanamycin can impact cellular processes related to ARP-1 functions.

17-AAG

75747-14-7sc-200641
sc-200641A
1 mg
5 mg
$66.00
$153.00
16
(2)

17-AAG, an Hsp90 inhibitor similar to Geldanamycin, indirectly modulates ARP-1 by disrupting its interaction with Hsp90, leading to ARP-1 degradation. The influence on ARP-1 levels by 17-AAG can affect cellular processes where ARP-1 plays a role.

Heat Shock Protein Inhibitor I

218924-25-5sc-221709
5 mg
$95.00
5
(1)

Heat Shock Protein Inhibitor I (KNK437), a selective Hsp70 inhibitor, indirectly influences ARP-1 stability by affecting Hsp70-mediated processes. ARP-1 is known to interact with Hsp70, and the disruption of this interaction by KNK437 may lead to alterations in ARP-1 levels, influencing cellular processes where ARP-1 is involved.

Withaferin A

5119-48-2sc-200381
sc-200381A
sc-200381B
sc-200381C
1 mg
10 mg
100 mg
1 g
$127.00
$572.00
$4090.00
$20104.00
20
(1)

Withaferin A, a natural compound, indirectly modulates ARP-1 by affecting its interaction with Hsp90. The disruption of the ARP-1-Hsp90 interaction by Withaferin A may lead to ARP-1 degradation, influencing cellular processes where ARP-1 plays a role.

Celastrol, Celastrus scandens

34157-83-0sc-202534
10 mg
$155.00
6
(1)

Celastrol, a natural compound, indirectly impacts ARP-1 by modulating Hsp90-mediated processes. ARP-1 interacts with Hsp90, and Celastrol disrupts this interaction, leading to ARP-1 degradation. The modulation of ARP-1 levels by Celastrol can affect cellular processes where ARP-1 plays a role.

2-Deoxy-D-glucose

154-17-6sc-202010
sc-202010A
1 g
5 g
$65.00
$210.00
26
(2)

2-Deoxyglucose (2-DG) indirectly influences ARP-1 by targeting glycolytic pathways. ARP-1, being sensitive to metabolic changes, may be affected by 2-DG-induced alterations in glycolysis, leading to changes in ARP-1 levels and cellular processes where ARP-1 is involved.

NVP-AUY922

747412-49-3sc-364551
sc-364551A
sc-364551B
sc-364551C
sc-364551D
sc-364551E
5 mg
25 mg
100 mg
250 mg
1 g
5 g
$150.00
$263.00
$726.00
$1400.00
$2900.00
$11000.00
3
(1)

AUY922 is an Hsp90 inhibitor that indirectly modulates ARP-1 by disrupting its interaction with Hsp90. The resulting degradation of ARP-1 induced by AUY922 can influence cellular processes where ARP-1 plays a role.