Arnt 2 Antibody (B-5): sc-393613

Arnt 2 Antibody (B-5) is a mouse monoclonal IgG2a antibody that detects Arnt 2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Arnt 2, also known as aryl hydrocarbon receptor nuclear translocator 2, is a crucial transcription factor that plays a significant role in mediating cellular responses to environmental signals, particularly in hypoxia and xenobiotic exposure. Arnt 2 is primarily located in the nucleus, where anti-Arnt 2 antibody (B-5) can detect heterodimers formed with the aromatic hydrocarbon receptor (AhR) to facilitate transcription of target genes involved in detoxification processes. Nuclear localization of Arnt 2 allows for precise regulation of gene expression in response to various stimuli, thereby influencing cellular metabolism and homeostasis. Arnt 2 (B-5) antibody recognizes the basic helix-loop-helix (bHLH) domain, which is essential for DNA binding, and PAS domains involved in protein-protein interactions. Arnt 2′s ability to interact with other proteins, such as AhR, underscores its importance in transcriptional regulation of genes that protect cells from toxic compounds, making Arnt 2 a key player in maintaining cellular health and responding to environmental challenges.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Arnt 2 Antibody (B-5) References:

1. The role of ARNT2 in tumor angiogenesis and the neural response to hypoxia.  |  Maltepe, E., et al. 2000. Biochem Biophys Res Commun. 273: 231-8. PMID: 10873592
2. Downregulation of ARNT2 promotes tumor growth and predicts poor prognosis in human hepatocellular carcinoma.  |  Li, W., et al. 2015. J Gastroenterol Hepatol. 30: 1085-93. PMID: 25611915
3. ARNT2 is downregulated and serves as a potential tumor suppressor gene in non-small cell lung cancer.  |  Yang, B., et al. 2015. Tumour Biol. 36: 2111-9. PMID: 25613063
4. ARNT2 Regulates Tumoral Growth in Oral Squamous Cell Carcinoma.  |  Kimura, Y., et al. 2016. J Cancer. 7: 702-10. PMID: 27076852
5. Overexpression of ARNT2 is associated with decreased cell proliferation and better prognosis in gastric cancer.  |  Jia, Y., et al. 2019. Mol Cell Biochem. 450: 97-103. PMID: 29948506
6. A viable hypomorphic Arnt2 mutation causes hyperphagic obesity, diabetes and hepatic steatosis.  |  Turer, EE., et al. 2018. Dis Model Mech. 11: PMID: 30563851
7. Oligodendrocyte ARNT2 expression is altered in models of MS.  |  Becquart, P., et al. 2020. Neurol Neuroimmunol Neuroinflamm. 7: PMID: 32439712
8. Structures of NPAS4-ARNT and NPAS4-ARNT2 heterodimers reveal new dimerization modalities in the bHLH-PAS transcription factor family.  |  Sun, X., et al. 2022. Proc Natl Acad Sci U S A. 119: e2208804119. PMID: 36343253
9. ARNT2 controls prefrontal somatostatin interneurons mediating affective empathy.  |  Choi, J., et al. 2024. Cell Rep. 43: 114659. PMID: 39180750
10. MYC-Mediated Inhibition of ARNT2 Uncovers a Key Tumor Suppressor in Glioblastoma.  |  Hao, YH., et al. 2024. Res Sq.. PMID: 39184078

The preferred Arnt 2 antibody is Arnt 2 Antibody (B-11): sc-393683.