ARL13B Antibody (C-5): sc-515784

ARL13B Antibody (C-5) is a mouse monoclonal IgG1 kappa light chain antibody that detects ARL13B protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-ARL13B antibody (C-5) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. ARL13B, also known as ADP-ribosylation factor-like 13B, is a 428 amino acid protein that plays a crucial role in cilia formation, which is essential for various cellular processes, including signaling pathways and fluid movement. Proper cilia function is vital for maintaining homeostasis in tissues and organs, and defects in ARL13B are linked to Joubert syndrome, a rare genetic disorder characterized by developmental issues in the brain, leading to symptoms such as ataxia, abnormal breathing, and seizures. ARL13B′s ability to regulate cilia formation highlights its importance in cellular architecture and function, making ARL13B monoclonal antibody (C-5) a valuable tool for researchers studying ciliary function and related disorders.

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ARL13B Antibody (C-5) References:

1. Mutations in a member of the Ras superfamily of small GTP-binding proteins causes Bardet-Biedl syndrome.  |  Fan, Y., et al. 2004. Nat Genet. 36: 989-93. PMID: 15314642
2. The graded response to Sonic Hedgehog depends on cilia architecture.  |  Caspary, T., et al. 2007. Dev Cell. 12: 767-78. PMID: 17488627
3. Joubert syndrome: a major brain malformation.  |  Ray, J., et al. 2007. J Indian Med Assoc. 105: 392-4. PMID: 18178993
4. Cerebellar development and disease.  |  Millen, KJ. and Gleeson, JG. 2008. Curr Opin Neurobiol. 18: 12-9. PMID: 18513948
5. Domain architecture of the atypical Arf-family GTPase Arl13b involved in cilia formation.  |  Hori, Y., et al. 2008. Biochem Biophys Res Commun. 373: 119-24. PMID: 18554500
6. Mutations in the cilia gene ARL13B lead to the classical form of Joubert syndrome.  |  Cantagrel, V., et al. 2008. Am J Hum Genet. 83: 170-9. PMID: 18674751
7. Joubert syndrome.  |  Sampathkumar, K., et al. 2008. Kidney Int. 74: 1222. PMID: 18854854
8. Arl13b-regulated cilia activities are essential for polarized radial glial scaffold formation.  |  Higginbotham, H., et al. 2013. Nat Neurosci. 16: 1000-7. PMID: 23817546
9. Identification of a novel ARL13B variant in a Joubert syndrome-affected patient with retinal impairment and obesity.  |  Thomas, S., et al. 2015. Eur J Hum Genet. 23: 621-7. PMID: 25138100
10. A function for the Joubert syndrome protein Arl13b in ciliary membrane extension and ciliary length regulation.  |  Lu, H., et al. 2015. Dev Biol. 397: 225-36. PMID: 25448689
11. Palmitoylation of the ciliary GTPase ARL13b is necessary for its stability and its role in cilia formation.  |  Roy, K., et al. 2017. J Biol Chem. 292: 17703-17717. PMID: 28848045
12. The Dynamic and Complex Role of the Joubert Syndrome-Associated Ciliary Protein, ADP-Ribosylation Factor-Like GTPase 13B (ARL13B) in Photoreceptor Development and Maintenance.  |  Dilan, T. and Ramamurthy, V. 2019. Adv Exp Med Biol. 1185: 501-505. PMID: 31884661

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ARL13B Antibody (C-5) has 11 citations in a variety of scientific publications.

Primary antibodies like Anti-ARL13B Antibody (C-5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ARL13B Antibody (C-5) Specifications

Alternate Product Name: ARL13B

Product Clone Name: C-5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 414-428

Epitope Target: ARL13B

Epitope Species: human

Product Reactivity/Detection: ARL13B

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 11 citations in various scientific publications

Available Conjugates/Forms for ARL13B Antibody (C-5): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin