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ARK-1 Antibody (C-1) is a mouse monoclonal IgG1 kappa light chain antibody that detects ARK-1 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). ARK-1 (C-1) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Aurora related kinase-1 (ARK-1), also known as STK15, Aurora2, and Aik1, is a centrosome-associated serine/threonine kinase that plays a crucial role in regulating centrosome separation, bipolar spindle assembly, and chromosome segregation during mitosis. Proper functioning of ARK-1 is vital for accurate cell division, as dysregulation can lead to aneuploidy and cancer. ARK-1 is predominantly localized in the nucleus and associates with distinct components of the mitotic machinery, particularly at the spindle poles during mitosis. ARK-1 protein levels are elevated in various colon carcinoma cell lines, such as HT-29 and SW480, and accumulates during metaphase in HeLa cells, highlighting potential as a biomarker for tumor progression. ARK-1 undergoes degradation after the G2/M phase via the ubiquitin-proteasome pathway, which is essential for maintaining proper cell cycle regulation. Expression of ARK-1 is particularly high in the human thymus and fetal liver, indicating importance in developmental processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Ordering Information
Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ARK-1 Antibody (C-1) | sc-398814 | 200 µg/ml | $316.00 | |||
ARK-1 Antibody (C-1): m-IgG Fc BP-HRP Bundle | sc-530939 | 200 µg Ab; 10 µg BP | $354.00 | |||
ARK-1 Antibody (C-1): m-IgGκ BP-HRP Bundle | sc-524499 | 200 µg Ab, 40 µg BP | $354.00 | |||
ARK-1 Antibody (C-1): m-IgG1 BP-HRP Bundle | sc-544326 | 200 µg Ab; 20 µg BP | $354.00 | |||
ARK-1 Antibody (C-1) AC | sc-398814 AC | 500 µg/ml, 25% agarose | $416.00 | |||
ARK-1 Antibody (C-1) HRP | sc-398814 HRP | 200 µg/ml | $316.00 | |||
ARK-1 Antibody (C-1) FITC | sc-398814 FITC | 200 µg/ml | $330.00 | |||
ARK-1 Antibody (C-1) PE | sc-398814 PE | 200 µg/ml | $343.00 | |||
ARK-1 Antibody (C-1) Alexa Fluor® 488 | sc-398814 AF488 | 200 µg/ml | $357.00 | |||
ARK-1 Antibody (C-1) Alexa Fluor® 546 | sc-398814 AF546 | 200 µg/ml | $357.00 | |||
ARK-1 Antibody (C-1) Alexa Fluor® 594 | sc-398814 AF594 | 200 µg/ml | $357.00 | |||
ARK-1 Antibody (C-1) Alexa Fluor® 647 | sc-398814 AF647 | 200 µg/ml | $357.00 | |||
ARK-1 Antibody (C-1) Alexa Fluor® 680 | sc-398814 AF680 | 200 µg/ml | $357.00 | |||
ARK-1 Antibody (C-1) Alexa Fluor® 790 | sc-398814 AF790 | 200 µg/ml | $357.00 |