ARIH1 Antibody (G-5): sc-514552

ARIH1 Antibody (G-5) is a mouse monoclonal IgG1 antibody that detects ARIH1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ARIH1, also known as ubiquitin conjugating enzyme E2 binding protein 1, ARI, HARI, HHARI, MOP-6, or UBCH7BP, is a 557 amino acid cytoplasmic protein that plays a crucial role in the regulation of protein degradation and translation. ARIH1 is characterized by the presence of two RING-type zinc fingers and one in-between RING fingers (IBR) domain, which are essential for its function as an E3 ubiquitin-protein ligase. ARIH1 interacts with UBCH7, facilitating the transfer of ubiquitin to specific substrates, thereby marking them for proteasomal degradation. Notably, ARIH1 polyubiquitylates eIF4E2, a key factor in the initiation of translation, which underscores its significance in controlling protein synthesis and maintaining cellular homeostasis. Anti-ARIH1 antibody (G-5) is an invaluable tool for researchers studying the dynamics of protein regulation and degradation pathways in various biological contexts.

The preferred ARIH1 antibody is ARIH1 Antibody (C-7): sc-514551.