ARIH1 Activators
ARIH1 activators belong to a unique and relatively novel class of chemical compounds that play a pivotal role in regulating protein homeostasis within the cell. ARIH1, also known as HHARI (Human Homolog of Drosophila Ariadne E3 Ubiquitin Protein Ligase), is an E3 ubiquitin ligase, an enzyme responsible for attaching ubiquitin molecules to specific target proteins, marking them for degradation or altering their functions. ARIH1 activators are compounds designed to enhance the activity of ARIH1, thereby influencing the ubiquitination and degradation of proteins in a highly selective and controlled manner.
These activators work by binding to ARIH1 and modifying its conformation or activity, ultimately leading to an increased ability to tag target proteins with ubiquitin. This process can have a profound impact on various cellular processes, such as protein turnover, quality control, and signal transduction. ARIH1 activators have garnered significant attention in the field of cell biology and proteostasis research due to their potential to modulate the levels of specific proteins, which can, in turn, affect cell function and, ultimately, the organism's physiological responses. Understanding and harnessing the power of ARIH1 activators offers the tantalizing prospect of fine-tuning protein regulation within cells.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic Acid is a natural toxin that indirectly influences ARIH1 by inhibiting protein phosphatases. This indirect modulation can lead to changes in phosphorylation events that may affect ARIH1 and its role in cellular signaling pathways. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000B sc-24000C | 10 µg 100 µg 500 µg 1 mg | $160.00 $750.00 $1400.00 $3000.00 | 59 | |
Calyculin A, a marine toxin and protein phosphatase inhibitor, indirectly impacts ARIH1 by altering phosphorylation patterns. These indirect effects on phosphorylation can, in turn, impact ARIH1 activity and its participation in cellular signaling pathways. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is an HDAC inhibitor that indirectly regulates ARIH1 by modifying gene expression through histone acetylation changes. These epigenetic modifications can indirectly influence ARIH1 expression and its involvement in cellular processes. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Vorinostat (SAHA), an HDAC inhibitor, indirectly impacts ARIH1 by altering histone acetylation and gene expression. These changes in gene expression indirectly affect ARIH1 levels and its potential role in cellular processes and protein regulation. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin, an mTOR inhibitor, indirectly influences ARIH1 by modulating mTOR signaling pathways. The indirect impact on mTOR can indirectly affect ARIH1 activity, contributing to its role in cellular processes and protein degradation. | ||||||
Everolimus | 159351-69-6 | sc-218452 sc-218452A | 5 mg 50 mg | $128.00 $638.00 | 7 | |
Everolimus, a derivative of rapamycin and mTOR inhibitor, indirectly regulates ARIH1 by affecting mTOR pathways. This indirect influence on mTOR can indirectly impact ARIH1 activation and its role in cellular processes and protein regulation. | ||||||