Arginase 2/ARG2 Antibody (C-8): sc-271443
- Arginase 2/ARG2 Antibody (C-8) is a mouse monoclonal IgG1 κ, cited in 5 publications, provided at 200 µg/ml
- raised against amino acids 291-354 of Arg2 of human origin
- Arginase 2/ARG2 Antibody (C-8) is recommended for detection of Arg2 of human origin by WB, IP, IF and ELISA
- Anti-Arginase 2/ARG2 Antibody (C-8) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for Arginase 2/ARG2 Antibody (C-8) for WB applications. These reagents are now offered in bundles with Arginase 2/ARG2 Antibody (C-8) (see ordering information below).
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Arg2 Antibody (C-8) is a mouse monoclonal IgG1 kappa light chain antibody specifically designed to target human Arginase 2 (ARG2), an enzyme localized in the mitochondria that plays a crucial role in the urea cycle and nitric oxide regulation. ARG2 catalyzes the hydrolysis of L-arginine into L-ornithine and urea, thereby contributing to L-arginine homeostasis and the biosynthesis of polyamines, which are essential for cell proliferation and differentiation. Also known as Type II Arginase, ARG2 is predominantly expressed in extrahepatic tissues like the kidney and small intestine, distinguishing ARG2 from Arginase 1 (ARG1), which is primarily found in the liver. The human ARG2 gene is located on chromosome 14q24.1 and encodes a 354 amino acid protein, whereas ARG1 is located on chromosome 6q23 and encodes a 322 amino acid protein. ARG2 contains a putative amino-terminal mitochondrial localization sequence, which directs ARG2 to the mitochondria, highlighting a unique subcellular distribution compared to ARG1. ARG2′s function is significant in modulating immune responses and vascular function, as ARG2 competes with nitric oxide synthase for L-arginine, influencing nitric oxide production and thus affecting endothelial function and blood pressure regulation. Dysregulation or overexpression of ARG2 has been implicated in various pathological conditions, including cardiovascular diseases, immune disorders, neurodegenerative diseases, and cancer, making ARG2 a critical target for biomedical research and therapeutic intervention. ARG2 (C-8) antibody was raised against amino acids 291–354 of human ARG2 and exhibits high specificity and affinity, demonstrating reactivity in western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ARG2 monoclonal antibody (C-8) is an invaluable tool for researchers aiming to detect ARG2 expression, elucidate biological functions, and explore roles in physiological and pathological processes, thereby advancing our understanding of cellular metabolism and disease mechanisms.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Arginase 2/ARG2 Antibody (C-8) | sc-271443 | 200 µg/ml | $322.00 | |||
Arg2 Antibody (C-8): m-IgG Fc BP-HRP Bundle | sc-527243 | 200 µg Ab; 10 µg BP | $361.00 | |||
Arg2 Antibody (C-8): m-IgG1 BP-HRP Bundle | sc-532616 | 200 µg Ab; 20 µg BP | $361.00 | |||
Arg2 Antibody (C-8) AC | sc-271443 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Arg2 Antibody (C-8) HRP | sc-271443 HRP | 200 µg/ml | $322.00 | |||
Arg2 Antibody (C-8) FITC | sc-271443 FITC | 200 µg/ml | $336.00 | |||
Arg2 Antibody (C-8) PE | sc-271443 PE | 200 µg/ml | $349.00 | |||
Arg2 Antibody (C-8) Alexa Fluor® 488 | sc-271443 AF488 | 200 µg/ml | $364.00 | |||
Arg2 Antibody (C-8) Alexa Fluor® 546 | sc-271443 AF546 | 200 µg/ml | $364.00 | |||
Arg2 Antibody (C-8) Alexa Fluor® 594 | sc-271443 AF594 | 200 µg/ml | $364.00 | |||
Arg2 Antibody (C-8) Alexa Fluor® 647 | sc-271443 AF647 | 200 µg/ml | $364.00 | |||
Arg2 Antibody (C-8) Alexa Fluor® 680 | sc-271443 AF680 | 200 µg/ml | $364.00 | |||
Arg2 Antibody (C-8) Alexa Fluor® 790 | sc-271443 AF790 | 200 µg/ml | $364.00 |