Aquaporin 5/AQP5 Antibody (D-7): sc-514022

AQP5 Antibody (D-7) is a mouse monoclonal IgG1 kappa light chain antibody that detects AQP5 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-AQP5 antibody (D-7) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. AQP5, a member of the aquaporin family, plays a crucial role in facilitating water transport across cell membranes, particularly in the lungs, where AQP5 is predominantly expressed in type I alveolar epithelial cells. This function is vital for maintaining proper hydration and surfactant homeostasis in the alveoli, which is essential for efficient gas exchange and overall respiratory function. Dysregulation of AQP5 has been implicated in various pulmonary disorders, highlighting AQP5′s importance in both normal physiology and disease states. AQP5′s ability to transport water rapidly makes AQP5 a key player in processes such as pulmonary secretion and the regulation of airway surface liquid, further underscoring AQP5′s significance in respiratory health.

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Aquaporin 5/AQP5 Antibody (D-7) References:

1. The mammalian aquaporin water channel family: A promising new drug target.  |  Beitz, E. and Schultz, JE. 1999. Curr Med Chem. 6: 457-67. PMID: 10213793
2. Lung fluid transport in aquaporin-5 knockout mice.  |  Ma, T., et al. 2000. J Clin Invest. 105: 93-100. PMID: 10619865
3. Isolation of the cDNA for erythrocyte integral membrane protein of 28 kilodaltons: member of an ancient channel family.  |  Preston, GM. and Agre, P. 1991. Proc Natl Acad Sci U S A. 88: 11110-4. PMID: 1722319
4. AQP5 enriches for stem cells and cancer origins in the distal stomach.  |  Tan, SH., et al. 2020. Nature. 578: 437-443. PMID: 32025032
5. AQP5 complements LGR5 to determine the fates of gastric cancer stem cells through regulating ULK1 ubiquitination.  |  Zhao, R., et al. 2022. J Exp Clin Cancer Res. 41: 322. PMID: 36372898
6. NNMT enriches for AQP5+ cancer stem cells to drive malignant progression in early gastric cardia adenocarcinoma.  |  Wang, Z., et al. 2023. Gut. 73: 63-77. PMID: 36977555
7. AQP5 deficiency promotes the senescence of lens epithelial cells through mitochondrial dysfunction.  |  Zhang, K., et al. 2023. Biochem Biophys Res Commun. 680: 184-193. PMID: 37742347
8. Structure and chromosomal localization of a human water channel (AQP3) gene.  |  Ishibashi, K., et al. 1995. Genomics. 27: 352-4. PMID: 7558005
9. cDNA cloning, gene organization, and chromosomal localization of a human mercurial insensitive water channel. Evidence for distinct transcriptional units.  |  Yang, B., et al. 1995. J Biol Chem. 270: 22907-13. PMID: 7559426
10. Requirement of human renal water channel aquaporin-2 for vasopressin-dependent concentration of urine.  |  Deen, PM., et al. 1994. Science. 264: 92-5. PMID: 8140421
11. The human Aquaporin-5 gene. Molecular characterization and chromosomal localization.  |  Lee, MD., et al. 1996. J Biol Chem. 271: 8599-604. PMID: 8621489
12. Aquaporins.  |  Echevarría, M. and Ilundáin, AA. 1998. J Physiol Biochem. 54: 107-18. PMID: 9858131

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Aquaporin 5/AQP5 Antibody (D-7) has 38 citations in a variety of scientific publications.

Primary antibodies like Anti-Aquaporin 5/AQP5 Antibody (D-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Aquaporin 5/AQP5 Antibody (D-7) Specifications

Alternate Product Name: aquaporin 5

Product Clone Name: D-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 66-265

Epitope Target: AQP5

Epitope Species: human

Product Reactivity/Detection: AQP5

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 38 citations in various scientific publications

Available Conjugates/Forms for Aquaporin 5/AQP5 Antibody (D-7): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin