Aquaporin 2/AQP2 Antibody (E13-21): sc-47710

AQP2 Antibody (E13-21) is a mouse monoclonal IgM antibody that detects AQP2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Anti-AQP2 antibody (E13-21) is available in both conjugated and non-conjugated forms, providing flexibility for various experimental needs. AQP2, a member of the aquaporin family, plays a crucial role in regulating water homeostasis in the body, particularly in the kidney′s collecting ducts, where AQP2 is uniquely activated by vasopressin to enhance water reabsorption. This function is vital for maintaining fluid balance and blood pressure, making AQP2 essential in the context of conditions such as diabetes insipidus and other disorders related to water retention. AQP2′s location within the cell membrane is significant, as AQP2 allows for the rapid transport of water in response to hormonal signals, thereby influencing urine concentration and overall hydration status. Understanding AQP2 dynamics and regulation can provide insights into therapeutic targets for kidney-related diseases and contribute to the development of treatments aimed at restoring normal water balance in affected individuals.

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Aquaporin 2/AQP2 Antibody (E13-21) References:

1. The mammalian aquaporin water channel family: A promising new drug target.  |  Beitz, E. and Schultz, JE. 1999. Curr Med Chem. 6: 457-67. PMID: 10213793
2. Isolation of the cDNA for erythrocyte integral membrane protein of 28 kilodaltons: member of an ancient channel family.  |  Preston, GM. and Agre, P. 1991. Proc Natl Acad Sci U S A. 88: 11110-4. PMID: 1722319
3. Micropeptide MIAC inhibits the tumor progression by interacting with AQP2 and inhibiting EREG/EGFR signaling in renal cell carcinoma.  |  Li, M., et al. 2022. Mol Cancer. 21: 181. PMID: 36117171
4. Proteomics and AQP2 regulation.  |  Yang, CR., et al. 2024. J Physiol. 602: 3011-3023. PMID: 36571566
5. LRBA signalosomes activate vasopressin-induced AQP2 trafficking at recycling endosomes.  |  Yanagawa, H., et al. 2023. J Physiol. 601: 5437-5451. PMID: 37860942
6. Cloning, characterization, and chromosomal mapping of human aquaporin of collecting duct.  |  Sasaki, S., et al. 1994. J Clin Invest. 93: 1250-6. PMID: 7510718
7. Structure and chromosomal localization of a human water channel (AQP3) gene.  |  Ishibashi, K., et al. 1995. Genomics. 27: 352-4. PMID: 7558005
8. cDNA cloning, gene organization, and chromosomal localization of a human mercurial insensitive water channel. Evidence for distinct transcriptional units.  |  Yang, B., et al. 1995. J Biol Chem. 270: 22907-13. PMID: 7559426
9. Requirement of human renal water channel aquaporin-2 for vasopressin-dependent concentration of urine.  |  Deen, PM., et al. 1994. Science. 264: 92-5. PMID: 8140421
10. The human Aquaporin-5 gene. Molecular characterization and chromosomal localization.  |  Lee, MD., et al. 1996. J Biol Chem. 271: 8599-604. PMID: 8621489
11. Expression and functional analysis of water channels in a stably AQP2-transfected human collecting duct cell line.  |  Valenti, G., et al. 1996. J Biol Chem. 271: 24365-70. PMID: 8798691
12. Aquaporins.  |  Echevarría, M. and Ilundáin, AA. 1998. J Physiol Biochem. 54: 107-18. PMID: 9858131

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Aquaporin 2/AQP2 Antibody (E13-21) has 5 citations in a variety of scientific publications.

Primary antibodies like Anti-Aquaporin 2/AQP2 Antibody (E13-21) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Aquaporin 2/AQP2 Antibody (E13-21) Specifications

Alternate Product Name: aquaporin 2

Product Clone Name: E13-21

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids:

Epitope Target: AQP2

Epitope Species: rat

Product Reactivity/Detection: AQP2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 5 citations in various scientific publications

Available Conjugates/Forms for Aquaporin 2/AQP2 Antibody (E13-21): AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790