AQP2 Activators
Common AQP2 Activators include, but are not limited to Vasopressin CAS 11000-17-2, Forskolin CAS 66575-29-9, Hydrochlorothiazide CAS 58-93-5, Desmopressin CAS 16679-58-6 and PMA CAS 16561-29-8.
AQP2 activators belong to a distinctive chemical class recognized for their capacity to modulate the activity of Aquaporin-2 (AQP2), a water channel protein that plays a crucial role in water reabsorption in the kidney's collecting ducts. These activators function by influencing the interactions and pathways involving AQP2, which facilitates the movement of water across cell membranes and is essential for maintaining body fluid balance and osmoregulation. AQP2 is a key component of the renal water conservation system, and its regulation is pivotal for maintaining proper hydration levels and electrolyte balance in the body. AQP2 activators are thoughtfully designed to target specific mechanisms or pathways associated with AQP2, thus influencing its cellular functions and the regulation of water transport.
The development of AQP2 activators necessitates a comprehensive understanding of the structural attributes of AQP2 and its interactions with cellular signaling molecules, regulatory proteins, and intracellular trafficking machinery. Researchers in this field work to engineer molecules that promote the activation of AQP2, contributing to its role in enhancing water reabsorption and preventing excessive water loss. These activators often employ innovative design strategies that enhance AQP2's functional role in regulating water permeability across cell membranes. By gaining insights into the intricate mechanisms through which AQP2 participates in water homeostasis and renal function, researchers aim to unravel its significance in fundamental physiological phenomena. Ongoing advancements in molecular pharmacology and chemical synthesis drive the refinement of AQP2 activators, offering applications across diverse scientific domains where manipulation of AQP2-mediated processes is of interest.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Vasopressin | 11000-17-2 | sc-356188 sc-356188A | 5 mg 25 mg | $260.00 $1040.00 | 1 | |
Vasopressin is a hormone that directly induces AQP2 expression in the kidney's collecting ducts, promoting water reabsorption and concentrating urine. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Compounds that increase cAMP levels, such as forskolin, stimulate AQP2 expression by activating the cAMP signaling pathway in the kidney. | ||||||
Desmopressin | 16679-58-6 | sc-391126 | 1 mg | $138.00 | ||
DDAVP is a synthetic form of vasopressin that specifically activates AQP2 expression, leading to increased water reabsorption in the kidney. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Phorbol esters can induce AQP2 expression by activating protein kinase C (PKC) and modulating signaling pathways in the kidney. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid, found in vitamin A, can influence AQP2 expression, affecting kidney function and water balance. | ||||||
Aldosterone | 52-39-1 | sc-210774 sc-210774A sc-210774B sc-210774C sc-210774D sc-210774E | 2 mg 5 mg 10 mg 50 mg 100 mg 250 mg | $105.00 $213.00 $317.00 $1550.00 $3074.00 $7637.00 | 1 | |
Aldosterone, a hormone, indirectly influences AQP2 expression by regulating sodium and potassium ion transport in the kidney. | ||||||
Angiotensin II, Human | 4474-91-3 | sc-363643 sc-363643A sc-363643B sc-363643C | 1 mg 5 mg 25 mg 100 mg | $51.00 $100.00 $310.00 $690.00 | 3 | |
Angiotensin II can stimulate AQP2 expression through its effects on the renin-angiotensin-aldosterone system and kidney function. | ||||||
Dopamine | 51-61-6 | sc-507336 | 1 g | $290.00 | ||
Dopamine can modulate AQP2 expression in the kidney, affecting water reabsorption and renal function. | ||||||
Prostaglandin G1 | 52162-11-5 | sc-215756 | 500 µg | $849.00 | ||
Certain prostaglandins can influence AQP2 expression by modulating renal function and water balance in the kidney. | ||||||