Apg-1 Antibody (B-7): sc-137007
- Apg-1 Antibody (B-7) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 231-838 of Apg-1 of human origin
- recommended for detection of Apg-1 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Apg-1 Antibody (B-7) for WB and IHC(P) applications. These reagents are now offered in bundles with Apg-1 Antibody (B-7) (see ordering information below).
Apg-1 Antibody (B-7) is a mouse monoclonal IgG1 antibody that detects Apg-1 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Apg-1, also known as HSPA4L or Osp94, is an 839 amino acid protein belonging to the HSP 110 family, which plays a crucial role in cellular stress responses by acting as a molecular chaperone. Apg-1 is primarily located in the cytoplasm and nucleus, where Apg-1 assists in proper protein folding and prevents protein aggregation, particularly under stress conditions such as heat shock. Nuclear translocation of Apg-1 following heat shock suggests a regulatory role in cellular stress response, potentially influencing gene expression and cellular survival. Anti-Apg-1 antibody (B-7) serves as an essential tool for researchers studying heat shock protein dynamics and their implications in various physiological and pathological processes.
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Apg-1 Antibody (B-7) References:
- Cloning of human cDNAs for Apg-1 and Apg-2, members of the Hsp110 family, and chromosomal assignment of their genes. | Nonoguchi, K., et al. 1999. Gene. 237: 21-8. PMID: 10524232
- Tor-mediated induction of autophagy via an Apg1 protein kinase complex. | Kamada, Y., et al. 2000. J Cell Biol. 150: 1507-13. PMID: 10995454
- Expression of Apg-1, a member of the Hsp110 family, in the human testis and sperm. | Nonoguchi, K., et al. 2001. Int J Urol. 8: 308-14. PMID: 11389747
- Regulation of expression of the stress response gene, Osp94: identification of the tonicity response element and intracellular signalling pathways. | Kojima, R., et al. 2004. Biochem J. 380: 783-94. PMID: 15018608
- Identification of an overexpressed gene, HSPA4L, the product of which can provoke prevalent humoral immune responses in leukemia patients. | Takahashi, H., et al. 2007. Exp Hematol. 35: 1091-9. PMID: 17588478
- Molecular cloning of OSP94: A significant biomarker protein of hypertensive human heart and a member of HSP110 family. | Mala, JG. and Takeuchi, S. 2009. Mol Biotechnol. 42: 175-94. PMID: 19169850
- Nogo-A couples with Apg-1 through interaction and co-ordinate expression under hypoxic and oxidative stress. | Kern, F., et al. 2013. Biochem J. 455: 217-27. PMID: 23909438
- The potent tumor suppressor miR-497 inhibits cancer phenotypes in nasopharyngeal carcinoma by targeting ANLN and HSPA4L. | Wang, S., et al. 2015. Oncotarget. 6: 35893-907. PMID: 26486082
- Osmotic stress protein 94 (Osp94). A new member of the Hsp110/SSE gene subfamily. | Kojima, R., et al. 1996. J Biol Chem. 271: 12327-32. PMID: 8647834
- Induction of Apg-1, a member of the heat shock protein 110 family, following transient forebrain ischemia in the rat brain. | Xue, JH., et al. 1998. Biochem Biophys Res Commun. 247: 796-801. PMID: 9647773
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Apg-1 Antibody (B-7) | sc-137007 | 200 µg/ml | $316.00 | |||
Apg-1 Antibody (B-7): m-IgG Fc BP-HRP Bundle | sc-537389 | 200 µg Ab; 10 µg BP | $354.00 | |||
Apg-1 Antibody (B-7): m-IgGκ BP-HRP Bundle | sc-534641 | 200 µg Ab; 40 µg BP | $354.00 | |||
Apg-1 Antibody (B-7): m-IgG1 BP-HRP Bundle | sc-545169 | 200 µg Ab; 20 µg BP | $354.00 |