AP-2μ1 Antibody (E-7): sc-515926

AP-2μ1 Antibody (E-7) is a mouse monoclonal IgG2a antibody that detects AP-2μ1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). AP-2μ1 is a crucial component of the adaptor protein complex 2 (AP-2), which plays a significant role in clathrin-mediated endocytosis, a vital cellular process for internalizing nutrients and signaling molecules. AP-2μ1 is primarily located at the plasma membrane and is essential for linking clathrin to specific receptors in coated vesicles, facilitating the transport of ligand-receptor complexes from the cell surface to intracellular compartments. Proper functioning of AP-2μ1 is critical for maintaining cellular homeostasis and regulating various signaling pathways, as disruptions in this process can lead to impaired endocytosis and contribute to various diseases, including cancer and neurodegenerative disorders. With AP-2μ1 (E-7) antibody′s ability to provide insights into the dynamics of endocytic pathways, this research tool proves invaluable for studying cellular transport mechanisms and their implications in health and disease.

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AP-2μ1 Antibody (E-7) References:

1. Identification and targeting of an interaction between a tyrosine motif within hepatitis C virus core protein and AP2M1 essential for viral assembly.  |  Neveu, G., et al. 2012. PLoS Pathog. 8: e1002845. PMID: 22916011
2. Regulation of senescence escape by the cdk4-EZH2-AP2M1 pathway in response to chemotherapy.  |  Le Duff, M., et al. 2018. Cell Death Dis. 9: 199. PMID: 29415991
3. The AP2M1 gene expression is a promising biomarker for predicting survival of patients with hepatocellular carcinoma.  |  Cho, SH., et al. 2019. J Cell Biochem. 120: 4140-4146. PMID: 30260026
4. A Recurrent Missense Variant in AP2M1 Impairs Clathrin-Mediated Endocytosis and Causes Developmental and Epileptic Encephalopathy.  |  Helbig, I., et al. 2019. Am J Hum Genet. 104: 1060-1072. PMID: 31104773
5. Regulation of BMP2K in AP2M1-mediated EGFR internalization during the development of gallbladder cancer.  |  Song, X., et al. 2020. Signal Transduct Target Ther. 5: 154. PMID: 32792513
6. AP2M1 Supports TGF-β Signals to Promote Collagen Expression by Inhibiting Caveolin Expression.  |  Lee, S., et al. 2021. Int J Mol Sci. 22: PMID: 33561975
7. Dysregulation of miR-138-5p/RPS6KA1-AP2M1 Is Associated With Poor Prognosis in AML.  |  Yu, DH., et al. 2021. Front Cell Dev Biol. 9: 641629. PMID: 33732707
8. Dysregulation of the AP2M1 phosphorylation cycle by LRRK2 impairs endocytosis and leads to dopaminergic neurodegeneration.  |  Liu, Q., et al. 2021. Sci Signal. 14: PMID: 34315807
9. High expression of AP2M1 correlates with worse prognosis by regulating immune microenvironment and drug resistance to R-CHOP in diffuse large B cell lymphoma.  |  Liu, X., et al. 2023. Eur J Haematol. 110: 198-208. PMID: 36335584
10. Identification of two new mu-adaptin-related proteins, mu-ARP1 and mu-ARP2.  |  Wang, X. and Kilimann, MW. 1997. FEBS Lett. 402: 57-61. PMID: 9013859

The preferred AP-2μ1 antibody is AP-2μ1 Antibody (D-7): sc-515920.