AP-2α Antibody (G8/5): sc-53164

AP-2α Antibody (G8/5) is a mouse monoclonal IgG1 antibody that detects AP-2α in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. AP-2α monoclonal antibody (G8/5) recognizes a crucial member of the AP-2 transcription factor family, which includes AP-2β and AP-2γ, and is known for its role in binding to the DNA consensus sequence CCCCAGGC to initiate transcription of specific genes. AP-2α (G8/5) antibody targets a protein particularly important in the regulation of genes associated with ectodermal development and has been implicated in various developmental disorders; for instance, mutations in the AP-2α gene are linked to microphthalmia and corneal clouding, highlighting its significance in eye development. Anti-AP-2α antibody (G8/5) helps researchers study the formation of the OB2-1 transcription factor complex, which upregulates the proto-oncogene c-ErbB-2, often overexpressed in breast cancer, thus underscoring its potential role in oncogenesis. AP-2α (G8/5) monoclonal antibody provides a valuable tool for researchers studying these critical pathways and the implications of AP-2α in both normal development and disease states.

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AP-2α Antibody (G8/5) References:

1. Differential expression of AP-2gamma and AP-2alpha during human trophoblast differentiation.  |  Richardson, BD., et al. 2001. Life Sci. 69: 2157-65. PMID: 11669459
2. Critical role for transcription factor AP-2alpha in human trophoblast differentiation.  |  Cheng, YH., et al. 2004. Physiol Genomics. 18: 99-107. PMID: 15039486
3. AP-2alpha and AP-2gamma are transcriptional targets of p53 in human breast carcinoma cells.  |  Li, H., et al. 2006. Oncogene. 25: 5405-15. PMID: 16636674
4. CK2 phosphorylates AP-2α and increases its transcriptional activity.  |  Ren, K., et al. 2011. BMB Rep. 44: 490-5. PMID: 21777522
5. AP-2α is required after lens vesicle formation to maintain lens integrity.  |  Kerr, CL., et al. 2014. Dev Dyn. 243: 1298-309. PMID: 24753151
6. Regulation of DEK expression by AP-2α and methylation level of DEK promoter in hepatocellular carcinoma.  |  Qiao, MX., et al. 2016. Oncol Rep. 36: 2382-90. PMID: 27499261
7. AP-2α Regulates S-Phase and Is a Marker for Sensitivity to PI3K Inhibitor Buparlisib in Colon Cancer.  |  Beck, AC., et al. 2021. Mol Cancer Res. 19: 1156-1167. PMID: 33753551
8. Prognostic significance of AP-2α/γ targets as cancer therapeutics.  |  Kołat, D., et al. 2022. Sci Rep. 12: 5497. PMID: 35361846
9. Transcription factors AP-2α and AP-2β regulate distinct segments of the distal nephron in the mammalian kidney.  |  Lamontagne, JO., et al. 2022. Nat Commun. 13: 2226. PMID: 35468900
10. Determination of WWOX Function in Modulating Cellular Pathways Activated by AP-2α and AP-2γ Transcription Factors in Bladder Cancer.  |  Kołat, D., et al. 2022. Cells. 11: PMID: 35563688

The preferred AP-2α antibody is AP-2α Antibody (3B5): sc-12726.