AP-180 Antibody (LP2D11): sc-21709

AP-180 Antibody (LP2D11) is a mouse monoclonal IgG1 antibody that detects AP-180 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). AP-180, also known as SNAP91, is a crucial 907 amino acid cell membrane protein that plays a significant role in receptor-mediated endocytosis by facilitating the assembly of clathrin-coated pits and vesicles. AP-180 contains an epsin N-terminal homology (ENTH) domain, which is essential for interaction with clathrin triskelia, promoting the formation of 60-70 nm coats necessary for vesicle transport. AP-180′s ability to bind clathrin is vital for proper functioning of the endocytic pathway, ensuring efficient internalization of membrane receptors and other cargo, thereby regulating various cellular processes such as nutrient uptake and signal transduction. AP-180 exists in three alternatively spliced isoforms, and AP-180′s gene is located on human chromosome 6q14.2 and mouse chromosome 9 E3.1, highlighting evolutionary conservation and importance across species. Anti-AP-180 antibody (LP2D11) is an invaluable tool for researchers studying clathrin-mediated endocytosis and related cellular mechanisms.

The preferred AP-180 antibody is AP-180 Antibody (B-10): sc-393266.