Annexin VIII Antibody (F-12): sc-393542

Annexin VIII Antibody (F-12) is a mouse monoclonal IgG2b kappa light chain antibody designed to detect Annexin VIII, also known as ANXA8, or Annexin A8-like 1 (ANXA8L1), across various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Annexin VIII monoclonal antibody (F-12) targets a precise epitope within amino acids 297-326 at the C-terminus of human Annexin VIII, ensuring selective and reliable binding. Annexin VIII is a member of the annexin family of calcium-binding proteins, characterized by a conserved core domain that facilitates phospholipid binding in a calcium-dependent manner, and plays a crucial role in regulating membrane dynamics, ion flux, endocytosis, exocytosis, and cellular adhesion. The ability of anti-Annexin VIII antibody (F-12) to interact with specific partners such as calmodulin and protein kinase C (PKC) underscores its importance in cellular signaling pathways and membrane organization, making Annexin VIII vital for processes like hematopoietic cell differentiation and apoptosis. These interactions are essential for maintaining cellular homeostasis and responding to environmental stimuli, highlighting Annexin VIII′s role in both normal physiological functions and pathological conditions. Annexin VIII is predominantly expressed at lower levels compared to Annexin V in most tissues but is markedly upregulated in acute promyelocytic leukemia (APL) cells, suggesting potential as a biomarker for certain malignancies. Anti-Annexin VIII antibody (F-12) exhibits high reactivity with human Annexin VIII and is also cross-reactive with mouse and rat Annexin VIII, providing versatility for studies across different model organisms. Available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates, Annexin VIII monoclonal antibody (F-12) offers flexible options to meet diverse experimental needs.

The preferred Annexin V antibody is Annexin V Antibody (H-3): sc-74438.