Annexin VI Antibody (G-10): sc-166807

Annexin VI Antibody (G-10) is a mouse monoclonal IgG2b antibody that detects Annexin VI in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Annexin VI is a member of the annexin family of calcium-binding proteins, which play crucial roles in cellular processes such as ion flux, endocytosis, exocytosis, and cellular adhesion. Annexin VI is characterized by a conserved core domain that binds to phospholipids in a calcium-dependent manner, along with a unique amino-terminal region that may provide binding specificity. Notably, Annexin VI has been shown to influence cellular behavior; for instance, Annexin VI overexpression in A-431 cells can partially reverse the transformed phenotype, suggesting a potential role as a tumor suppressor. Furthermore, growth-dependent post-translational modifications of Annexin VI are essential for proper sub-cellular localization, which is critical for function in cellular signaling and membrane dynamics. Annexin VI interactions with various cellular components underscore importance in maintaining cellular homeostasis and responding to stress signals, making Annexin VI a valuable target for research in cancer and muscle diseases.

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Annexin VI Antibody (G-10) References:

1. Annexin VI stimulates endocytosis and is involved in the trafficking of low density lipoprotein to the prelysosomal compartment.  |  Grewal, T., et al. 2000. J Biol Chem. 275: 33806-13. PMID: 10940299
2. Annexin V, annexin VI, S100A1 and S100B in developing and adult avian skeletal muscles.  |  Arcuri, C., et al. 2002. Neuroscience. 109: 371-88. PMID: 11801372
3. Annexin VI regulation of cardiac function.  |  Kaetzel, MA. and Dedman, JR. 2004. Biochem Biophys Res Commun. 322: 1171-7. PMID: 15336965
4. Two translation initiation codons direct the expression of annexin VI 64kDa and 68kDa isoforms.  |  González-Noriega, A., et al. 2016. Mol Genet Metab. 119: 338-343. PMID: 27743858
5. Annexin VI has tumour-suppressor activity in human A431 squamous epithelial carcinoma cells.  |  Theobald, J., et al. 1995. Br J Cancer. 71: 786-8. PMID: 7710945
6. Annexin VI, a marker protein of hepatocytic endosomes.  |  Jäckle, S., et al. 1994. J Biol Chem. 269: 1026-32. PMID: 7904597
7. Annexin VI-binding proteins in brain. Interaction of annexin VI with a membrane skeletal protein, calspectin (brain spectrin or fodrin).  |  Watanabe, T., et al. 1994. J Biol Chem. 269: 17656-62. PMID: 8021276
8. Annexin VI overexpression targeted to heart alters cardiomyocyte function in transgenic mice.  |  Gunteski-Hamblin, AM., et al. 1996. Am J Physiol. 270: H1091-100. PMID: 8780208
9. Annexin VI-mediated loss of spectrin during coated pit budding is coupled to delivery of LDL to lysosomes.  |  Kamal, A., et al. 1998. J Cell Biol. 142: 937-47. PMID: 9722607
10. Annexin VI binds S100A1 and S100B and blocks the ability of S100A1 and S100B to inhibit desmin and GFAP assemblies into intermediate filaments.  |  Garbuglia, M., et al. 1998. Cell Calcium. 24: 177-91. PMID: 9883272

The preferred Annexin VI antibody is Annexin VI Antibody (E-5): sc-271859.