Annexin VI Antibody (E-5): sc-271859

Annexin VI Antibody (E-5) is a mouse monoclonal IgG1 kappa light chain antibody that detects Annexin VI protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-Annexin VI antibody (E-5) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Annexin VI, also known as ANXA6, plays a crucial role in cellular processes such as membrane trafficking and ion flux regulation, particularly in response to calcium levels. Calcium-dependent phospholipid binding by Annexin VI maintains cellular integrity and facilitates cell-to-cell communication. A conserved core domain and distinct amino-terminal region in Annexin VI enables interactions with various membrane components, influencing endocytosis and exocytosis. Changes in Annexin VI expression or localization have been linked to pathological conditions, including cancer, where overexpression can partially reverse transformed phenotypes in certain cell lines. Anti-Annexin VI antibody (E-5) serves as an essential tool for researchers studying these vital cellular processes and disease mechanisms.

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Annexin VI Antibody (E-5) References:

1. Annexin VI participates in the formation of a reversible, membrane-cytoskeleton complex in smooth muscle cells.  |  Babiychuk, EB., et al. 1999. J Biol Chem. 274: 35191-5. PMID: 10575003
2. Identification of annexin VI as a Ca2+-sensitive CRHSP-28-binding protein in pancreatic acinar cells.  |  Thomas, DD., et al. 2002. J Biol Chem. 277: 35496-502. PMID: 12105190
3. A growth-dependent post-translational modification of annexin VI.  |  Moss, SE., et al. 1992. Biochim Biophys Acta. 1160: 120-6. PMID: 1420329
4. Co-distribution of annexin VI and actin in secretory ameloblasts and odontoblasts of rat incisor.  |  Goldberg, M., et al. 1991. Cell Tissue Res. 263: 81-9. PMID: 1826233
5. Structural evolution of the annexin supergene family.  |  Smith, PD. and Moss, SE. 1994. Trends Genet. 10: 241-6. PMID: 8091504
6. Annexin VII relocalization as a result of dystrophin deficiency.  |  Selbert, S., et al. 1996. Exp Cell Res. 222: 199-208. PMID: 8549664
7. Calcium-dependent binding of S100C to the N-terminal domain of annexin I.  |  Mailliard, WS., et al. 1996. J Biol Chem. 271: 719-25. PMID: 8557678
8. Functional and genetic analysis of annexin VI.  |  Edwards, HC. and Moss, SE. 1995. Mol Cell Biochem. 149-150: 293-9. PMID: 8569744
9. Annexin II tetramer: structure and function.  |  Waisman, DM. 1995. Mol Cell Biochem. 149-150: 301-22. PMID: 8569746
10. Annexin II in exocytosis: catecholamine secretion requires the translocation of p36 to the subplasmalemmal region in chromaffin cells.  |  Chasserot-Golaz, S., et al. 1996. J Cell Biol. 133: 1217-36. PMID: 8682860
11. Isoform-specific intracellular vesicle formation by recombinant annexin XI-A in Sf9 cells.  |  Sudo, T., et al. 1996. Biochem Biophys Res Commun. 223: 706-11. PMID: 8687461
12. Annexin VI modulates Ca2+ and K+ conductances of spinal cord and dorsal root ganglion neurons.  |  Naciff, JM., et al. 1996. Am J Physiol. 271: C2004-15. PMID: 8997203

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Annexin VI Antibody (E-5) has 9 citations in a variety of scientific publications.

Primary antibodies like Anti-Annexin VI Antibody (E-5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Annexin VI Antibody (E-5) Specifications

Alternate Product Name: Annexin VI

Product Clone Name: E-5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 5-27

Epitope Target: Annexin VI

Epitope Species: human

Product Reactivity/Detection: Annexin VI

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 9 citations in various scientific publications

Available Conjugates/Forms for Annexin VI Antibody (E-5): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin