Annexin VI Antibody (C-4): sc-365582

Annexin VI Antibody (C-4) is a mouse monoclonal IgG1 antibody that detects Annexin VI in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Annexin VI is a member of the annexin family of calcium-binding proteins, which play crucial roles in various cellular processes, including ion flux, endocytosis, exocytosis, and cellular adhesion. Annexin VI is characterized by a conserved core domain that binds to phospholipids in a calcium-dependent manner, along with a unique amino-terminal region that may provide binding specificity. Notably, Annexin VI has been shown to influence cellular behavior; when overexpressed in A-431 cells, Annexin VI can partially reverse the transformed phenotype, suggesting a potential role as a tumor suppressor. Furthermore, growth-dependent post-translational modifications of Annexin VI are essential for proper sub-cellular localization, which is critical for maintaining cellular integrity and signaling. Anti-Annexin VI antibody (C-4) serves as an invaluable tool for researchers studying protein dynamics in various biological contexts, including involvement in disease states such as muscular dystrophy, where localization is altered.

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Annexin VI Antibody (C-4) References:

1. Inhibition of EGF-dependent calcium influx by annexin VI is splice form-specific.  |  Fleet, A., et al. 1999. Biochem Biophys Res Commun. 260: 540-6. PMID: 10403803
2. Mapping the site of interaction between annexin VI and the p120GAP C2 domain.  |  Chow, A. and Gawler, D. 1999. FEBS Lett. 460: 166-72. PMID: 10571081
3. Annexin VI is attached to transverse-tubule membranes in isolated skeletal muscle triads.  |  Barrientos, G. and Hidalgo, C. 2002. J Membr Biol. 188: 163-73. PMID: 12172641
4. Characterization of a recombinant form of annexin VI for detection of apoptosis.  |  Smith, C., et al. 2010. Bioconjug Chem. 21: 1554-8. PMID: 20672837
5. Modulation of Ca2+ release channel activity from sarcoplasmic reticulum by annexin VI (67-kDa calcimedin).  |  Díaz-Muñoz, M., et al. 1990. J Biol Chem. 265: 15894-9. PMID: 2168425
6. Kinetics of annexin VI, calcium, and phospholipid association and dissociation.  |  Lu, Y., et al. 1995. Biochemistry. 34: 10777-85. PMID: 7662658
7. Endocytosis occurs independently of annexin VI in human A431 cells.  |  Smythe, E., et al. 1994. J Cell Biol. 124: 301-6. PMID: 7905003
8. Expression of annexin VI in A431 carcinoma cells suppresses proliferation: a possible role for annexin VI in cell growth regulation.  |  Theobald, J., et al. 1994. Biochim Biophys Acta. 1223: 383-90. PMID: 7918674
9. Voltage dependent binding of annexin V, annexin VI and annexin VII-core to acidic phospholipid membranes.  |  Hofmann, A., et al. 1997. Biochim Biophys Acta. 1330: 254-64. PMID: 9408179
10. Localization of annexin VI in the adult and neonatal heart.  |  Luckcuck, T., et al. 1998. Cell Biol Int. 22: 199-205. PMID: 9974214

The preferred Annexin VI antibody is Annexin VI Antibody (E-5): sc-271859.