Annexin A9 Antibody (G-4): sc-365940

Annexin A9 Antibody (G-4) is a mouse monoclonal IgG1 antibody that detects Annexin A9 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Annexin A9, also known as Annexin-31 or Pemphaxin, is a 345 amino acid protein characterized by four Annexin domains, which play a crucial role in binding phospholipids in a calcium-dependent manner. Notably, Annexin A9 is an atypical member of the annexin family, as intracellular activity is not regulated by calcium due to specific sequence mutations. This unique feature allows Annexin A9 to function independently of calcium fluctuations, which is significant for its role in cellular processes. Furthermore, Annexin A9 has been implicated in the pathogenesis of pemphigus vulgaris, a rare autoimmune skin disorder where autoantibodies target this protein, leading to a loss of cell-cell adhesion and the formation of blisters in the epidermis. Anti-Annexin A9 antibody (G-4) is an essential tool for researchers studying the molecular mechanisms underlying autoimmune diseases and the diverse functions of annexin proteins in cellular physiology.

The preferred Annexin A9 antibody is Annexin A9 Antibody (F-9): sc-374288.