Ankyrin G Antibody (H-4): sc-166602

Ankyrin G Antibody (H-4) is a mouse monoclonal IgG2b antibody that detects Ankyrin G in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Ankyrin G is a crucial member of the Ankyrin family of proteins, which play a vital role in linking integral membrane proteins to the cytoskeleton, thereby maintaining cellular structure and function. Anti-Ankyrin G antibody (H-4) is predominantly localized at the nodes of Ranvier and axon initial segments in neurons, where Ankyrin G is essential for the proper functioning of sodium channels, facilitating the rapid propagation of action potentials. The unique structure of Ankyrin G, characterized by its large size and multiple isoforms generated through alternative mRNA processing, allows for tissue-specific functions, with the largest isoforms primarily expressed in nervous tissue and smaller variants found in other organs such as the lung, kidney, spleen, liver, and heart. The ability of Ankyrin G to interact with various proteins, including sodium channels and other cytoskeletal components, underscores its importance in neuronal signaling and overall cellular integrity. Ankyrin G monoclonal antibody (H-4) enables researchers to gain valuable insights into the role of Ankyrin G in health and disease, particularly in neurological contexts.

The preferred Ankyrin G antibody is Ankyrin G Antibody (463): sc-12719.