Ankyrin G Antibody (A-7): sc-137105
- Ankyrin G Antibody (A-7) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against amino acids 4163-4377 mapping at the C-terminus of Ankyrin G of human origin
- recommended for detection of Ankyrin G of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- See Ankyrin G (463): sc-12719 for Ankyrin G antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Ankyrin G Antibody (A-7) for WB and IHC(P) applications. These reagents are now offered in bundles with Ankyrin G Antibody (A-7) (see ordering information below).
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Ankyrin G Antibody (A-7) is a mouse monoclonal IgG1 antibody that detects Ankyrin G in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Ankyrin G plays a crucial role in maintaining neuronal cell integrity by anchoring integral membrane proteins to the cytoskeleton, which is vital for proper cellular signaling and function. Anti-Ankyrin G antibody (A-7) targets proteins predominantly localized at the nodes of Ranvier and axon initial segments, where Ankyrin G is essential for sodium channel regulation and action potential propagation in neurons. Ankyrin G′s unique structure, characterized by multiple isoforms generated through alternative mRNA processing, allows for tissue-specific functions, with largest isoforms primarily expressed in nervous tissue and smaller variants found in organs like lung, kidney, spleen, liver, and heart. Ankyrin G′s interaction with various proteins, including sodium channels, underscores Ankyrin G′s importance in neuronal excitability and cellular communication, making anti-Ankyrin G antibody (A-7) an invaluable research tool for studying neuronal function and related pathologies.
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Ankyrin G Antibody (A-7) References:
- Ankyrin-G and beta2-spectrin collaborate in biogenesis of lateral membrane of human bronchial epithelial cells. | Kizhatil, K., et al. 2007. J Biol Chem. 282: 2029-37. PMID: 17074766
- Connexin43 regulates sodium current; ankyrin-G modulates gap junctions: the intercalated disc exchanger. | Delmar, M. 2012. Cardiovasc Res. 93: 220-2. PMID: 22180603
- Ankyrin-G regulates neurogenesis and Wnt signaling by altering the subcellular localization of β-catenin. | Durak, O., et al. 2015. Mol Psychiatry. 20: 388-97. PMID: 24821222
- Ankyrin-G coordinates intercalated disc signaling platform to regulate cardiac excitability in vivo. | Makara, MA., et al. 2014. Circ Res. 115: 929-38. PMID: 25239140
- Giant ankyrin-G stabilizes somatodendritic GABAergic synapses through opposing endocytosis of GABAA receptors. | Tseng, WC., et al. 2015. Proc Natl Acad Sci U S A. 112: 1214-9. PMID: 25552561
- Ankyrin-G isoform imbalance and interneuronopathy link epilepsy and bipolar disorder. | Lopez, AY., et al. 2017. Mol Psychiatry. 22: 1464-1472. PMID: 27956739
- Novel Mechanistic Roles for Ankyrin-G in Cardiac Remodeling and Heart Failure. | Makara, MA., et al. 2018. JACC Basic Transl Sci. 3: 675-689. PMID: 30456339
- Ankyrin-G regulates forebrain connectivity and network synchronization via interaction with GABARAP. | Nelson, AD., et al. 2020. Mol Psychiatry. 25: 2800-2817. PMID: 30504823
- Ankyrin G organizes membrane components to promote coupling of cell mechanics and glucose uptake. | Salvi, AM., et al. 2021. Nat Cell Biol. 23: 457-466. PMID: 33972734
- Palmitoylation controls the stability of 190 kDa ankyrin-G in dendritic spines and is regulated by ZDHHC8 and lithium. | Piguel, NH., et al. 2023. Front Mol Neurosci. 16: 1144066. PMID: 36969554
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ankyrin G Antibody (A-7) | sc-137105 | 200 µg/ml | $322.00 | |||
Ankyrin G Antibody (A-7): m-IgG Fc BP-HRP Bundle | sc-537401 | 200 µg Ab; 10 µg BP | $361.00 | |||
Ankyrin G Antibody (A-7): m-IgGκ BP-HRP Bundle | sc-534656 | 200 µg Ab; 40 µg BP | $361.00 | |||
Ankyrin G Antibody (A-7): m-IgG1 BP-HRP Bundle | sc-545174 | 200 µg Ab; 20 µg BP | $361.00 |