Ankyrin B Antibody (G-11): sc-365757

Ankyrin B Antibody (G-11) is a mouse monoclonal IgG1 antibody that detects Ankyrin B in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Ankyrin B plays a crucial role in maintaining neuronal integrity and function, primarily by anchoring integral membrane proteins to the cytoskeleton, which is vital for proper cellular signaling and structural stability. Anti-Ankyrin B antibody (G-11) recognizes protein predominantly located in the plasma membrane of neurons and glial cells throughout the brain, where Ankyrin B facilitates the organization of the spectrin-actin cytoskeletal network. Ankyrin B at these sites is essential for the coordinated assembly of various ion channels and receptors, including the sodium/calcium exchanger and sodium/potassium ATPase, which are critical for maintaining ionic balance and excitability in cardiomyocytes. Alternative splicing of Ankyrin B results in multiple isoforms, allowing for functional diversity and adaptability in different cellular contexts. Ankyrin B (G-11) antibody serves as an invaluable tool for researchers studying neuronal function, cytoskeletal dynamics, and the molecular mechanisms underlying various neurological disorders.

The preferred Ankyrin B antibody is Ankyrin B Antibody (2.20): sc-12718.