Ankyrin B Antibody (2.20): sc-12718
- Ankyrin B Antibody (2.20) is a mouse monoclonal IgG1 λ Ankyrin B antibody, cited in 7 publications, provided at 200 µg/ml
- raised against the spectrin binding domain of Ankyrin B of human origin
- Ankyrin B Antibody (2.20) is recommended for detection of Ankyrin B of mouse, rat and human origin by WB, IP and IF
- Anti-Ankyrin B Antibody (2.20) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgGλ BP-HRP (mouse IgGλ binding protein-HRP) is the preferred secondary detection reagent for Ankyrin B Antibody (2.20) for WB applications. This reagent is now offered in a bundle with Ankyrin B Antibody (2.20) (see ordering information below). For additional m-IgGλ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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Ankyrin B Antibody (2.20) is a mouse monoclonal IgG1 antibody that detects Ankyrin B protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Anti-Ankyrin B antibody (2.20) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Ankyrin B plays a crucial role in maintaining the structural integrity of neurons by anchoring integral membrane proteins to the cytoskeleton, which is vital for proper neuronal signaling and function. Ankyrin B (2.20) monoclonal antibody is predominantly localized in the plasma membrane of neurons and glial cells, where Ankyrin B interacts with the spectrin-actin cytoskeletal network. This localization is essential for the stabilization of axon bundles and the coordinated assembly of key ion transporters, such as the Na/Ca exchanger and Na/K ATPase, at critical sites in cardiomyocytes. Alternative splicing of Ankyrin B results in multiple isoforms, further diversifying functional roles in cellular processes. The importance of Ankyrin B in neuronal function and interactions with other proteins underscore significance in both health and disease, making anti-Ankyrin B antibody (2.20) a valuable tool for researchers studying neuronal dynamics and related pathologies.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Ankyrin B Antibody (2.20) References:
- Physiological roles of axonal ankyrins in survival of premyelinated axons and localization of voltage-gated sodium channels. | Bennett, V. and Lambert, S. 1999. J Neurocytol. 28: 303-18. PMID: 10739573
- Expression of sodium channel SNS/PN3 and ankyrin(G) mRNAs in the trigeminal ganglion after inferior alveolar nerve injury in the rat. | Bongenhielm, U., et al. 2000. Exp Neurol. 164: 384-95. PMID: 10915577
- Ankyrin-B mutation causes type 4 long-QT cardiac arrhythmia and sudden cardiac death. | Mohler, PJ., et al. 2003. Nature. 421: 634-9. PMID: 12571597
- Inositol 1,4,5-trisphosphate receptor localization and stability in neonatal cardiomyocytes requires interaction with ankyrin-B. | Mohler, PJ., et al. 2004. J Biol Chem. 279: 12980-7. PMID: 14722080
- Isoform specificity among ankyrins. An amphipathic alpha-helix in the divergent regulatory domain of ankyrin-b interacts with the molecular co-chaperone Hdj1/Hsp40. | Mohler, PJ., et al. 2004. J Biol Chem. 279: 25798-804. PMID: 15075330
- A cardiac arrhythmia syndrome caused by loss of ankyrin-B function. | Mohler, PJ., et al. 2004. Proc Natl Acad Sci U S A. 101: 9137-42. PMID: 15178757
- Ankyrin-B targets beta2-spectrin to an intracellular compartment in neonatal cardiomyocytes. | Mohler, PJ., et al. 2004. J Biol Chem. 279: 40185-93. PMID: 15262991
- Restriction of 480/270-kD ankyrin G to axon proximal segments requires multiple ankyrin G-specific domains. | Zhang, X. and Bennett, V. 1998. J Cell Biol. 142: 1571-81. PMID: 9744885
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ankyrin B Antibody (2.20) | sc-12718 | 200 µg/ml | $316.00 | |||
Ankyrin B Antibody (2.20): m-IgGλ BP-HRP Bundle | sc-520579 | 200 µg Ab, 40 µg BP | $354.00 | |||
Ankyrin B Antibody (2.20) AC | sc-12718 AC | 500 µg/ml, 25% agarose | $416.00 | |||
Ankyrin B Antibody (2.20) HRP | sc-12718 HRP | 200 µg/ml | $316.00 | |||
Ankyrin B Antibody (2.20) FITC | sc-12718 FITC | 200 µg/ml | $330.00 | |||
Ankyrin B Antibody (2.20) PE | sc-12718 PE | 200 µg/ml | $343.00 | |||
Ankyrin B Antibody (2.20) Alexa Fluor® 488 | sc-12718 AF488 | 200 µg/ml | $357.00 | |||
Ankyrin B Antibody (2.20) Alexa Fluor® 546 | sc-12718 AF546 | 200 µg/ml | $357.00 | |||
Ankyrin B Antibody (2.20) Alexa Fluor® 594 | sc-12718 AF594 | 200 µg/ml | $357.00 | |||
Ankyrin B Antibody (2.20) Alexa Fluor® 647 | sc-12718 AF647 | 200 µg/ml | $357.00 | |||
Ankyrin B Antibody (2.20) Alexa Fluor® 680 | sc-12718 AF680 | 200 µg/ml | $357.00 | |||
Ankyrin B Antibody (2.20) Alexa Fluor® 790 | sc-12718 AF790 | 200 µg/ml | $357.00 |