AMZ2 Antibody (E-4): sc-365345

AMZ2 Antibody (E-4) is a mouse monoclonal IgG2a kappa light chain antibody that detects AMZ2 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). AMZ2 (E-4) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. AMZ2, also known as archaelysin family metallopeptidase 2 or archaemetzincin-2, is a 360 amino acid protein that belongs to the peptidase M54 family and is encoded by a gene located on human chromosome 17q24.2. AMZ2 is predominantly expressed in the heart and testis, but can also be found in the kidney, liver, pancreas, lung, brain, and placenta, as well as in fetal tissues such as kidney, liver, lung, and brain. AMZ2 plays a crucial role in metal ion binding and functions as a zinc metalloprotease, which is important for various physiological processes, including the regulation of peptide hormones. AMZ2 exhibits aminopeptidase activity, specifically acting against Angiotensin in vitro, although AMZ2 does not hydrolyze Neurogranin or Angiotensin. Notably, AMZ2 is significantly inhibited by Epiamastatin hydrochloride, an aminopeptidase inhibitor, as well as general metalloprotease inhibitors like o-phenanthroline and batimastat, highlighting AMZ2′s potential as a target for therapeutic intervention in conditions where metalloprotease activity is dysregulated.

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AMZ2 Antibody (E-4) References:

1. Identification and characterization of human archaemetzincin-1 and -2, two novel members of a family of metalloproteases widely distributed in Archaea.  |  Díaz-Perales, A., et al. 2005. J Biol Chem. 280: 30367-75. PMID: 15972818
2. Recruitment of a novel zinc-bound transcriptional factor by a bacterial HMGA-type protein is required for regulating multiple processes in Myxococcus xanthus.  |  Peñalver-Mellado, M., et al. 2006. Mol Microbiol. 61: 910-26. PMID: 16879646
3. A role for archaeal organisms in development of atherosclerotic vulnerable plaques and myxoid matrices.  |  Higuchi, ML., et al. 2006. Clinics (Sao Paulo). 61: 473-8. PMID: 17072447
4. The Degradome database: mammalian proteases and diseases of proteolysis.  |  Quesada, V., et al. 2009. Nucleic Acids Res. 37: D239-43. PMID: 18776217
5. The regulatory action of the myxobacterial CarD/CarG complex: a bacterial enhanceosome?  |  Elías-Arnanz, M., et al. 2010. FEMS Microbiol Rev. 34: 764-78. PMID: 20561058
6. Crystal structure of archaemetzincin AmzA from Methanopyrus kandleri at 1.5 A resolution.  |  Waltersperger, S., et al. 2010. Proteins. 78: 2720-3. PMID: 20597090

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-AMZ2 Antibody (E-4) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-AMZ2 Antibody (E-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

AMZ2 Antibody (E-4) Specifications

Alternate Product Name: AMZ2

Product Clone Name: E-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 1-270

Epitope Target: AMZ2

Epitope Species: human

Product Reactivity/Detection: AMZ2

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for AMZ2 Antibody (E-4): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin