αB-crystallin Antibody (A-7): sc-137143

αB-crystallin Antibody (A-7) is a mouse monoclonal IgG1 antibody that detects αB-crystallin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). αB-crystallin is a member of the small heat shock protein family and plays a crucial role in cellular stress response by acting as a molecular chaperone, preventing the aggregation of denatured proteins and maintaining cellular protein homeostasis. This function is particularly important in tissues that are subject to high levels of stress, such as the lens of the eye, heart, and skeletal muscle, where αB-crystallin is abundantly expressed. Notably, αB-crystallin′s ability to form large soluble aggregates allows for sequestering misfolded proteins, thereby protecting cells from proteotoxicity. Dysregulation of αB-crystallin expression has been linked to various neurological diseases, highlighting its significance in maintaining cellular integrity under stress conditions. Anti-αB-crystallin antibody (A-7) is an essential tool for researchers studying αB-crystallin′s role in health and disease, providing insights into its involvement in conditions such as Desmin-related myopathy and congenital cataracts.

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αB-crystallin Antibody (A-7) References:

1. Alpha B-crystallin exists as an independent protein in the heart and in the lens.  |  Bhat, SP., et al. 1991. Eur J Biochem. 202: 775-81. PMID: 1765091
2. Alpha B-crystallin - a validated prognostic factor for poor prognosis in squamous cell carcinoma of the oral cavity.  |  Annertz, K., et al. 2014. Acta Otolaryngol. 134: 543-50. PMID: 24702231
3. Alpha B-crystallin is expressed in kidney epithelial cell lines and not in fibroblasts.  |  Nagineni, CN. and Bhat, SP. 1989. FEBS Lett. 249: 89-94. PMID: 2470619
4. Alpha-B-crystallin expression in human laryngeal squamous cell carcinoma tissues.  |  Yilmaz, M., et al. 2015. Head Neck. 37: 1344-8. PMID: 24817638
5. Expression of alpha B crystallin and BCL2 in patients with infiltrating ductal carcinoma.  |  Kim, MS., et al. 2015. Int J Clin Exp Pathol. 8: 8842-56. PMID: 26464626
6. Alpha-B-Crystallin Effect on Mature Amyloid Fibrils: Different Degradation Mechanisms and Changes in Cytotoxicity.  |  Stepanenko, OV., et al. 2020. Int J Mol Sci. 21: PMID: 33081200
7. Association of Alpha B-Crystallin Expression with Tumor Differentiation Grade in Colorectal Cancer Patients.  |  Pagano, C., et al. 2021. Diagnostics (Basel). 11: PMID: 34069924
8. Alpha B crystallin expression in response to hormone, oncogenes and stress.  |  Klemenz, R., et al. 1994. Verh Dtsch Ges Pathol. 78: 34-5. PMID: 7534008
9. Alpha B-crystallin expression in mouse NIH 3T3 fibroblasts: glucocorticoid responsiveness and involvement in thermal protection.  |  Aoyama, A., et al. 1993. Mol Cell Biol. 13: 1824-35. PMID: 8441415
10. alpha B-crystallin and hsp25 in neonatal cardiac cells--differences in cellular localization under stress conditions.  |  van de Klundert, FA., et al. 1998. Eur J Cell Biol. 75: 38-45. PMID: 9523153

The preferred αB-crystallin antibody is αB-crystallin Antibody (F-10): sc-137129.