alpha Synuclein Antibody (211): sc-12767

α-synuclein Antibody (211) is a mouse monoclonal IgG1 kappa light chain antibody engineered to target the human α-synuclein protein, also known as SNCA, synuclein, or NACP. Anti-α-synuclein antibody (211) recognizes the epitope encompassing amino acids 121-125 of α-synuclein, facilitating detection through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP) applications. α-synuclein is a pivotal protein primarily expressed in neuronal cell bodies and synapses, where α-synuclein plays a crucial role in synaptic regulation and neuronal plasticity, essential for maintaining proper brain function and facilitating communication between neurons. α-synuclein is deeply involved in synaptic vesicle trafficking and neurotransmitter release, processes vital for efficient neuronal signaling. α-synuclein is implicated in the pathogenesis of several neurodegenerative diseases, including Parkinson′s disease and Alzheimer′s disease, where abnormal aggregation is a hallmark of disease progression. Additionally, α-synuclein expression is modulated during hematopoietic cell differentiation, indicating broader significance in cellular processes beyond the nervous system. α-synuclein monoclonal antibody (211) is available in both unconjugated form and various conjugated forms, such as horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates, providing researchers with versatile options for different experimental needs. α-synuclein (211) antibody is an invaluable tool for scientists investigating the molecular mechanisms of synuclein-related disorders and exploring the physiological functions of α-synuclein in both the nervous system and hematopoietic cells.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

alpha Synuclein Antibody (211) References:

1. The precursor protein of non-A beta component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system.  |  Iwai, A., et al. 1995. Neuron. 14: 467-75. PMID: 7857654
2. Identification of two distinct synucleins from human brain.  |  Jakes, R., et al. 1994. FEBS Lett. 345: 27-32. PMID: 8194594
3. Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease.  |  Uéda, K., et al. 1993. Proc Natl Acad Sci U S A. 90: 11282-6. PMID: 8248242
4. Mutation in the alpha-synuclein gene identified in families with Parkinson's disease.  |  Polymeropoulos, MH., et al. 1997. Science. 276: 2045-7. PMID: 9197268
5. NACP, a synaptic protein involved in Alzheimer's disease, is differentially regulated during megakaryocyte differentiation.  |  Hashimoto, M., et al. 1997. Biochem Biophys Res Commun. 237: 611-6. PMID: 9299413

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-alpha Synuclein Antibody (211) has 222 citations in a variety of scientific publications.

Primary antibodies like Anti-alpha Synuclein Antibody (211) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

alpha Synuclein Antibody (211) Specifications

Alternate Product Name: alpha synuclein

Product Clone Name: 211

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 121-125

Epitope Target: α-synuclein

Epitope Species: human

Product Reactivity/Detection: α-synuclein

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 222 citations in various scientific publications

Available Conjugates/Forms for alpha Synuclein Antibody (211): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin