α-sarcoglycan Antibody (G-11): sc-515299

α-sarcoglycan Antibody (G-11) is a mouse monoclonal IgG2b antibody that detects α-sarcoglycan in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). α-sarcoglycan is a crucial component of the dystrophin-associated protein complex, which plays a vital role in maintaining the structural integrity of muscle cell membranes. α-sarcoglycan (G-11) antibody targets proteins primarily located in the cell membrane of skeletal, cardiac, and smooth muscle fibers, where α-sarcoglycan forms a complex with other sarcoglycan subunits, including β-, γ-, and δ-sarcoglycan. Proper localization of α-sarcoglycan is essential for the stability of the entire dystrophin complex, and any genetic defects affecting α-sarcoglycan can lead to severe muscle disorders, such as sarcoglycanopathy, characterized by muscle weakness and degeneration. Furthermore, α-sarcoglycan interaction with other proteins in the dystrophin complex is critical for effective signal transduction and muscle function, highlighting α-sarcoglycan importance in both normal physiology and disease states. anti-α-sarcoglycan antibody (G-11) is an invaluable tool for researchers studying muscle biology and related pathologies, providing insights into the mechanisms underlying muscular dystrophies and potential therapeutic targets.

The preferred α-sarcoglycan antibody is α-sarcoglycan Antibody (D-7): sc-271321.