α-internexin Antibody (G-9): sc-271302

α-internexin Antibody (G-9) is a mouse monoclonal IgG1 kappa light chain antibody that detects alpha-internexin protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). α-internexin Antibody (G-9) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Alpha-internexin is a brain-specific type IV intermediate filament protein that plays a crucial role in the structural integrity and function of neurons within the central nervous system. This axonal protein is predominantly located in the cytoplasm of neurons, where alpha-internexin contributes to the formation of a resilient filament network essential for maintaining neuronal shape and stability. The head domain of alpha-internexin is particularly important for self-assembly into this filamentous structure, which is vital for neuronal development and function. Notably, alpha-internexin expression levels peak during late embryogenesis and decline into adulthood, indicating a significant role in the regulatory processes that govern brain development. Furthermore, alpha-internexin promoter is activated by transcription factors Brn-3a and Brn-3c, while Brn-3b binding leads to repression, highlighting the complex regulatory mechanisms that control alpha-internexin expression during neuronal maturation.

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α-internexin Antibody (G-9) References:

1. alpha-internexin is present in the pathological inclusions of neuronal intermediate filament inclusion disease.  |  Cairns, NJ., et al. 2004. Am J Pathol. 164: 2153-61. PMID: 15161649
2. Alpha-internexin as a corneal autoantigen in spontaneous autoimmune keratitis mouse model.  |  Hattori, T., et al. 2006. Invest Ophthalmol Vis Sci. 47: 249-55. PMID: 16384970
3. α-Internexin in the diagnosis of oligodendroglial tumors and association with 1p/19q status.  |  Eigenbrod, S., et al. 2011. J Neuropathol Exp Neurol. 70: 970-8. PMID: 22002423
4. Alpha-internexin, a novel neuronal intermediate filament protein, precedes the low molecular weight neurofilament protein (NF-L) in the developing rat brain.  |  Kaplan, MP., et al. 1990. J Neurosci. 10: 2735-48. PMID: 2201753
5. alpha-Internexin, a 66-kD intermediate filament-binding protein from mammalian central nervous tissues.  |  Pachter, JS. and Liem, RK. 1985. J Cell Biol. 101: 1316-22. PMID: 2413040
6. Coexpression of cyclin D1 and alpha-internexin in oligodendroglial tumors.  |  Matsumura, N., et al. 2015. Brain Tumor Pathol. 32: 261-7. PMID: 26233522
7. Prognostic relevance of UCH-L1 and α-internexin in pancreatic neuroendocrine tumors.  |  Song, YL., et al. 2017. Sci Rep. 7: 2205. PMID: 28526880
8. Compartmentation of alpha-internexin and neurofilament triplet proteins in cultured hippocampal neurons.  |  Benson, DL., et al. 1996. J Neurocytol. 25: 181-96. PMID: 8737171
9. alpha-Internexin is the only neuronal intermediate filament expressed in developing cerebellar granule neurons.  |  Chien, CL., et al. 1996. J Neurobiol. 29: 304-18. PMID: 8907160
10. Molecular parameters of type IV alpha-internexin and type IV-type III alpha-internexin-vimentin copolymer intermediate filaments.  |  Steinert, PM., et al. 1999. J Biol Chem. 274: 1657-66. PMID: 9880545

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-α-internexin Antibody (G-9) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-α-internexin Antibody (G-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

α-internexin Antibody (G-9) Specifications

Alternate Product Name: α-internexin

Product Clone Name: G-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 410-499

Epitope Target: α-internexin

Epitope Species: human

Product Reactivity/Detection: α-internexin

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for α-internexin Antibody (G-9): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin