α E-catenin Antibody (G-11): sc-9988

α E-catenin Antibody (G-11) is a mouse monoclonal IgG1 kappa light chain antibody that detects α E-catenin of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. α E-catenin Antibody (G-11) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. α E-catenin, also known as cadherin-associated protein alpha 1, plays a crucial role in cell-cell adhesion by linking E-cadherin to the cytoskeleton through interactions with β- or γ-catenin and actin filaments. This connection maintains the integrity of adherens junctions, which are essential for tissue architecture and cellular communication. α E-catenin is abundant in neuroepithelial precursor cells within the developing cortical ventricular zone of the brain, where α E-catenin contributes to the regulation of cell density and the developmental hedgehog signaling pathway. Interactions between α E-catenin and vinculin are particularly important for the assembly of the apical junction complex in epithelial tissues, highlighting α E-catenin′s role in maintaining cellular structure and function. Disruption of this adhesion complex can lead to the detachment of cancer cells from primary tumors, potentially facilitating invasion and metastasis, making α E-catenin a significant focus in cancer research.

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α E-catenin Antibody (G-11) References:

1. The alphaE-catenin gene (CTNNA1) acts as an invasion-suppressor gene in human colon cancer cells.  |  Vermeulen, SJ., et al. 1999. Oncogene. 18: 905-15. PMID: 10023666
2. The human alphaE-catenin gene CTNNA1: mutational analysis and rare occurrence of a truncated splice variant.  |  Vanpoucke, G., et al. 2002. Biochim Biophys Acta. 1574: 262-8. PMID: 11997091
3. Alpha-catenin is required for IGF-I-induced cellular migration but not invasion in human colonic cancer cells.  |  André, F., et al. 2004. Oncogene. 23: 1177-86. PMID: 14961074
4. Differential expression of alpha-E-catenin and alpha-N-catenin in the developing cerebral cortex.  |  Stocker, AM. and Chenn, A. 2006. Brain Res. 1073-1074: 151-8. PMID: 16457793
5. alphaE-catenin controls cerebral cortical size by regulating the hedgehog signaling pathway.  |  Lien, WH., et al. 2006. Science. 311: 1609-12. PMID: 16543460
6. Alpha-E-catenin binds to dynamitin and regulates dynactin-mediated intracellular traffic.  |  Lien, WH., et al. 2008. J Cell Biol. 183: 989-97. PMID: 19075109
7. α(E)-catenin regulates BMP-7 expression and migration in renal epithelial cells.  |  Nichols, LA., et al. 2014. Am J Nephrol. 39: 409-17. PMID: 24818804
8. Loss of α(E)-catenin potentiates cisplatin-induced nephrotoxicity via increasing apoptosis in renal tubular epithelial cells.  |  Wang, X., et al. 2014. Toxicol Sci. 141: 254-62. PMID: 24973089
9. α-E-Catenin (CTNNA1) Inhibits Cell Proliferation, Invasion and EMT of Bladder Cancer.  |  Chi, Q., et al. 2020. Cancer Manag Res. 12: 12747-12758. PMID: 33364826
10. Alpha 1(E)-catenin is an actin-binding and -bundling protein mediating the attachment of F-actin to the membrane adhesion complex.  |  Rimm, DL., et al. 1995. Proc Natl Acad Sci U S A. 92: 8813-7. PMID: 7568023
11. Molecular cloning of an alternative human alphaE-catenin cDNA.  |  Linkels, M., et al. 1997. Biochem Biophys Res Commun. 237: 177-81. PMID: 9266853
12. alpha-Catenin-vinculin interaction functions to organize the apical junctional complex in epithelial cells.  |  Watabe-Uchida, M., et al. 1998. J Cell Biol. 142: 847-57. PMID: 9700171

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-α E-catenin Antibody (G-11) has 38 citations in a variety of scientific publications.

Primary antibodies like Anti-α E-catenin Antibody (G-11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

α E-catenin Antibody (G-11) Specifications

Alternate Product Name: CTNNA1

Product Clone Name: G-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 610-906514660

Epitope Target: α E-catenin

Epitope Species: human

Product Reactivity/Detection: α E-catenin

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine, canine and bovine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 38 citations in various scientific publications

Available Conjugates/Forms for α E-catenin Antibody (G-11): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin