α E-catenin Antibody (1G5): sc-47753

α E-catenin Antibody (1G5) is a mouse monoclonal IgG1 antibody that detects α E-catenin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). α E-catenin, also known as cadherin-associated protein α1, plays a crucial role in E-cadherin-mediated cell-cell adhesion by linking E-cadherin to the cytoskeleton via interactions with β- or γ-catenin and actin filaments. α E-catenin is essential for maintaining the integrity of adherens junctions, which are vital for tissue architecture and cellular communication. α E-catenin is predominantly located in the neuroepithelial precursor cells of the developing cortical ventricular zone in the brain, where α E-catenin is involved in regulating cell density and the developmental hedgehog signaling pathway. The interactions between α E-catenin and vinculin are particularly important for the assembly of the apical junction complex in epithelial tissues, highlighting α E-catenin′s role in maintaining cellular structure and function. Disruption of this adhesion complex can lead to the detachment of cancer cells from primary tumors, potentially facilitating invasion and metastasis, making α E-catenin a significant focus in cancer research. With its ability to provide insights into cell adhesion mechanisms and tumor biology, anti-α E-catenin antibody (1G5) is an invaluable tool for researchers studying these critical processes.

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α E-catenin Antibody (1G5) References:

1. Differential expression of alpha-E-catenin and alpha-N-catenin in the developing cerebral cortex.  |  Stocker, AM. and Chenn, A. 2006. Brain Res. 1073-1074: 151-8. PMID: 16457793
2. alpha-E-catenin inactivation disrupts the cardiomyocyte adherens junction, resulting in cardiomyopathy and susceptibility to wall rupture.  |  Sheikh, F., et al. 2006. Circulation. 114: 1046-55. PMID: 16923756
3. Alpha(E)-Catenin induces SRF-dependent transcriptional activity through its C-terminal region and is partly RhoA/ROCK-dependent.  |  Merdek, KD., et al. 2008. Biochem Biophys Res Commun. 366: 717-23. PMID: 18078809
4. An α-E-catenin (CTNNA1) mutation in hereditary diffuse gastric cancer.  |  Majewski, IJ., et al. 2013. J Pathol. 229: 621-9. PMID: 23208944
5. A role for the age-dependent loss of α(E)-catenin in regulation of N-cadherin expression and cell migration.  |  Nichols, LA., et al. 2014. Physiol Rep. 2: PMID: 24920123
6. Loss of α(E)-catenin promotes Fas mediated apoptosis in tubular epithelial cells.  |  Wang, X. and Parrish, AR. 2015. Apoptosis. 20: 921-9. PMID: 25894537
7. Glucose regulates expression of pro-inflammatory genes, IL-1β and IL-12, through a mechanism involving hexosamine biosynthesis pathway-dependent regulation of α-E catenin.  |  Dissanayake, WC., et al. 2021. Biosci Rep. 41: PMID: 34139004
8. Isolation and characterization of a human pseudogene (CTNNAP1) for alpha E-catenin (CTNNA1): assignment of the pseudogene to 5q22 and the alpha E-catenin gene to 5q31.  |  Nollet, F., et al. 1995. Genomics. 26: 410-3. PMID: 7601473
9. Molecular cloning reveals alternative splice forms of human alpha(E)-catenin.  |  Rimm, DL., et al. 1994. Biochem Biophys Res Commun. 203: 1691-9. PMID: 7945318
10. Structure, expression and chromosome assignment of the human catenin (cadherin-associated protein) alpha 1 gene (CTNNA1).  |  Furukawa, Y., et al. 1994. Cytogenet Cell Genet. 65: 74-8. PMID: 8404069

The preferred α E-catenin antibody is α E-catenin Antibody (G-11): sc-9988.