α-Dystrobrevin Antibody (B-2): sc-376689

α-Dystrobrevin Antibody (B-2) is a mouse monoclonal IgG2b antibody that detects α-Dystrobrevin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). α-Dystrobrevin is a crucial component of the dystrophin glycoprotein complex, which plays a significant role in maintaining the structural integrity of muscle cells and facilitating synapse maturation. α-Dystrobrevin is primarily localized to the cytoplasmic side of the sarcolemma and is particularly concentrated at the neuromuscular junctions in skeletal muscle, highlighting its importance in muscle function and signaling. α-Dystrobrevin is essential for normal muscle contraction and communication between nerve and muscle cells, and disruption can lead to severe muscular disorders, including Duchenne muscular dystrophy. Alternative splicing of α-Dystrobrevin results in various isoforms, such as γ-Dystrobrevin, δ-Dystrobrevin, ε-Dystrobrevin, and ζ-Dystrobrevin, which may have distinct roles in different tissues, further underscoring the complexity and significance of this protein in muscle physiology and pathology. α-Dystrobrevin antibody (B-2) is an invaluable tool for researchers studying muscle-related diseases and the underlying mechanisms of synaptic function.

The preferred Dystrobrevin antibody is Dystrobrevin Antibody (C-6): sc-271874.