α-actinin-4 Antibody (A-8): sc-393495

α-actinin-4 Antibody (A-8) is a mouse monoclonal IgG1 kappa light chain antibody that detects α-actinin-4 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). α-actinin-4 (A-8) antibody is offered in both non-conjugated and multiple conjugated forms, such as agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and various Alexa Fluor® conjugates. α-actinin-4 plays a crucial role in the cytoskeleton by functioning as a bundling protein that cross-links filamentous actin (F-actin), thereby anchoring actin to various intracellular structures, which is essential for maintaining cell shape and facilitating cellular movement. α-actinin-4 is predominantly localized in muscle and non-muscle cells, including skeletal, cardiac, and smooth muscle cells, where α-actinin-4 contributes to the structural integrity and mechanical properties of the cytoskeleton. Mutations in the gene encoding α-actinin-4 have been linked to focal segmental glomerulosclerosis 1 (FSGS1), a serious renal condition characterized by progressive kidney dysfunction and potential renal failure, highlighting α-actinin-4′s significance in both cellular architecture and disease pathology.

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Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-α-actinin-4 Antibody (A-8) has 13 citations in a variety of scientific publications.

Primary antibodies like Anti-α-actinin-4 Antibody (A-8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

α-actinin-4 Antibody (A-8) Specifications

Alternate Product Name: α-actinin-4

Product Clone Name: A-8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-22

Epitope Target: α-actinin-4

Epitope Species: human

Product Reactivity/Detection: α-actinin-4

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: canine, bovine and porcine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 13 citations in various scientific publications

Available Conjugates/Forms for α-actinin-4 Antibody (A-8): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin

The preferred α-actinin antibody is α-actinin Antibody (H-2): sc-17829.