Aldose Reductase Antibody (F-10): sc-133130

Aldose Reductase Antibody (F-10) is a mouse monoclonal IgG1 antibody that detects Aldose Reductase in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Aldose Reductase, also known as ALR2, is a crucial enzyme in the monomeric NADPH-dependent aldoketoreductase family, primarily responsible for catalyzing the reduction of aldehydes to their corresponding alcohols, such as the conversion of glucose to sorbitol. This enzymatic activity is particularly significant in the context of diabetic complications, as the accumulation of sorbitol in cells due to hyperglycemia can lead to osmotic stress, contributing to conditions like neuropathy, retinopathy, and cataracts. Aldose Reductase′s location within the cytoplasm is vital, as this positioning allows for rapid response to elevated glucose levels, facilitating the conversion process that, while minor in normal glucose metabolism, becomes detrimental in diabetic states. Aldose Reductase shares structural similarities with other proteins, including human aldehyde reductase (ALR1) and bovine prostaglandin F synthase, highlighting evolutionary conservation and functional importance across species. Anti-Aldose Reductase antibody (F-10) serves as an essential tool for researchers investigating this enzyme′s role in metabolic disorders and potential as a therapeutic target.

The preferred Aldose Reductase antibody is Aldose Reductase Antibody (H-6): sc-166918.