Aldose Reductase Antibody (E-12): sc-373953

Aldose Reductase Antibody (E-12) is a mouse monoclonal IgG2a antibody that detects Aldose Reductase in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Aldose Reductase plays a crucial role in cellular metabolism by catalyzing the reduction of aldehydes, particularly converting glucose into sorbitol, which is significant in the context of diabetic complications. While this pathway is generally minor in glucose metabolism across most tissues, excessive sorbitol accumulation during diabetic hyperglycemia leads to hyperosmotic stress on cells. This stress contributes to various diabetic complications, including neuropathy, retinopathy, and cataracts, highlighting Aldose Reductase′s importance in understanding and potentially mitigating these conditions. Aldose Reductase shares structural similarities with human aldehyde reductase (ALR1), bovine prostaglandin F synthase, and the European common frog protein, rho-crystallin, underscoring evolutionary significance and functional similarities across species.

The preferred Aldose Reductase antibody is Aldose Reductase Antibody (H-6): sc-166918.