Aldehyde dehydrogenase 4-A1/P5CDH/ALDH4A1 Antibody (E-4): sc-393339

ALDH4A1 Antibody (E-4) is a mouse monoclonal IgG2b antibody that detects ALDH4A1 in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). ALDH4A1, also known as P5CD (Delta-1-pyrroline-5-carboxylate dehydrogenase), plays a crucial role in the proline degradation pathway by catalyzing the conversion of Delta-1-pyrroline-5-carboxylate (P5C) to glutamate within the mitochondrial matrix. This enzymatic activity is vital for maintaining cellular homeostasis and regulating proline levels, which are essential for various metabolic processes, including the synthesis of neurotransmitters and the detoxification of harmful aldehydes. Dysregulation of ALDH4A1 due to mutations can lead to hyperprolinemia type II, a condition marked by elevated levels of proline and P5C, which can result in severe neurological impairments such as mental retardation and seizures. Anti-ALDH4A1 antibody (E-4) is an invaluable tool for researchers investigating the biochemical pathways involving proline metabolism and its implications in human health and disease.

The preferred Aldehyde dehydrogenase 4-A1/P5CDH/ALDH4A1 antibody is Aldehyde dehydrogenase 4-A1/P5CDH/ALDH4A1 Antibody (F-1): sc-398911.