Aldehyde dehydrogenase 4-A1/P5CDH/ALDH4A1 Antibody (F-1): sc-398911

ALDH4A1 Antibody (F-1) is a mouse monoclonal IgG1 kappa light chain antibody that detects ALDH4A1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ALDH4A1 (F-1) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. ALDH4A1 protein, also known as P5CD (Delta-1-pyrroline-5-carboxylate dehydrogenase), plays a crucial role in the proline degradation pathway by catalyzing the conversion of Delta-1-pyrroline-5-carboxylate to glutamate within the mitochondrial matrix. This enzymatic function is vital for maintaining cellular homeostasis and regulating proline levels, as an imbalance can lead to hyperprolinemia type II, a genetic disorder characterized by elevated proline and its precursor, which can result in neurological complications such as mental retardation and seizures. ALDH4A1′s ability to mediate the detoxification of aldehydes and involvement in amino acid metabolism underscores its importance in various physiological processes, making anti-ALDH4A1 antibody (F-1) an essential tool for researchers studying metabolic pathways and related disorders.

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Aldehyde dehydrogenase 4-A1/P5CDH/ALDH4A1 Antibody (F-1) References:

1. Eukaryotic aldehyde dehydrogenase (ALDH) genes: human polymorphisms, and recommended nomenclature based on divergent evolution and chromosomal mapping.  |  Vasiliou, V., et al. 1999. Pharmacogenetics. 9: 421-34. PMID: 10780262
2. Polymorphisms of human aldehyde dehydrogenases. Consequences for drug metabolism and disease.  |  Vasiliou, V. and Pappa, A. 2000. Pharmacology. 61: 192-8. PMID: 10971205
3. Identification of ALDH4 as a p53-inducible gene and its protective role in cellular stresses.  |  Yoon, KA., et al. 2004. J Hum Genet. 49: 134-140. PMID: 14986171
4. Type II hyperprolinemia: a case report.  |  Onenli-Mungan, N., et al. 2004. Turk J Pediatr. 46: 167-9. PMID: 15214748
5. Type II hyperprolinaemia in a pedigree of Irish travellers (nomads).  |  Flynn, MP., et al. 1989. Arch Dis Child. 64: 1699-707. PMID: 2624476
6. Defective hydroxyproline metabolism in type II hyperprolinemia.  |  Goodman, SI., et al. 1974. Biochem Med. 10: 329-36. PMID: 4851275
7. Regulation of levels of proline as an osmolyte in plants under water stress.  |  Yoshiba, Y., et al. 1997. Plant Cell Physiol. 38: 1095-102. PMID: 9399433
8. Mutations in the Delta1-pyrroline 5-carboxylate dehydrogenase gene cause type II hyperprolinemia.  |  Geraghty, MT., et al. 1998. Hum Mol Genet. 7: 1411-5. PMID: 9700195

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Aldehyde dehydrogenase 4-A1/P5CDH/ALDH4A1 Antibody (F-1) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-Aldehyde dehydrogenase 4-A1/P5CDH/ALDH4A1 Antibody (F-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Aldehyde dehydrogenase 4-A1/P5CDH/ALDH4A1 Antibody (F-1) Specifications

Alternate Product Name: ALDH4A1

Product Clone Name: F-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 261-288

Epitope Target: ALDH4A1

Epitope Species: human

Product Reactivity/Detection: ALDH4A1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for Aldehyde dehydrogenase 4-A1/P5CDH/ALDH4A1 Antibody (F-1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin