AKR7A Antibody (E-9): sc-137187

AKR7A Antibody (E-9) is a mouse monoclonal IgG2b antibody that detects AKR7A in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). AKR7A, a member of the aldo-keto reductase 7 family, plays a crucial role in the metabolism of Aflatoxin B1 and other dicarbonyl-containing compounds, which is vital for detoxifying environmental carcinogens and preventing cellular damage. AKR7A is predominantly expressed in the liver, where constitutive expression is essential for Aflatoxin elimination, thereby acting as an endogenous chemo-preventative agent. Notably, the human AKR7A2 gene, which encodes for AKR7A, is located on chromosome 1p36.13, a region often deleted in sporadic colorectal cancer, highlighting potential implications in cancer biology. Additionally, AKR7A3, another member of this family, functions as a homodimer and is expressed in various tissues, including the kidney, colon, pancreas, endometrium, and adenocarcinoma, further underscoring the importance of AKR7A proteins in diverse biological contexts. anti-AKR7A antibody (E-9) is an invaluable tool for researchers investigating metabolic pathways involving Aflatoxin and the role of AKR7A in cancer prevention and treatment.

The preferred AKR7A antibody is AKR7A Antibody (F-8): sc-137186.