AKR1C19 Antibody (A-1): sc-393680

AKR1C19 Antibody (A-1) is a mouse monoclonal IgG2a kappa light chain antibody that detects AKR1C19 of mouse and rat origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-AKR1C19 antibody (A-1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. AKR1C19, also known as aldo-keto reductase family 1, member C19, is a crucial enzyme involved in the metabolism of endogenous and exogenous compounds, including drugs and reactive aldehydes. AKR1C19 plays a vital role in detoxifying harmful substances and regulating steroid hormone levels, which can influence various physiological processes. AKR1C19 is encoded by a gene located on mouse chromosome 13, within a cluster of hydroxysteroid dehydrogenases, and consists of 323 amino acids. AKR1C19 interacts with other members of the aldo-keto reductase family, enhancing functional versatility and participating in various metabolic pathways crucial for maintaining cellular homeostasis and responding to environmental stressors.

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AKR1C19 Antibody (A-1) References:

1. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray.  |  Tanaka, TS., et al. 2000. Proc Natl Acad Sci U S A. 97: 9127-32. PMID: 10922068
2. Human 3alpha-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of the aldo-keto reductase superfamily: functional plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sex hormones.  |  Penning, TM., et al. 2000. Biochem J. 351: 67-77. PMID: 10998348
3. 17beta-Hydroxysteroid dehydrogenase type 9 and other short-chain dehydrogenases/reductases that catalyze retinoid, 17beta- and 3alpha-hydroxysteroid metabolism.  |  Napoli, JL. 2001. Mol Cell Endocrinol. 171: 103-9. PMID: 11165018
4. A cluster of eight hydroxysteroid dehydrogenase genes belonging to the aldo-keto reductase supergene family on mouse chromosome 13.  |  Vergnes, L., et al. 2003. J Lipid Res. 44: 503-11. PMID: 12562828
5. Enzymatic properties of a member (AKR1C19) of the aldo-keto reductase family.  |  Ishikura, S., et al. 2005. Biol Pharm Bull. 28: 1075-8. PMID: 15930748
6. Isolation and characterization of a cDNA encoding mouse 3alpha-hydroxysteroid dehydrogenase: an androgen-inactivating enzyme selectively expressed in female tissues.  |  Bellemare, V., et al. 2006. J Steroid Biochem Mol Biol. 98: 18-24. PMID: 16191478
7. Enzymatic properties of a member (AKR1C20) of the aldo-keto reductase family.  |  Matsumoto, K., et al. 2006. Biol Pharm Bull. 29: 539-42. PMID: 16508162
8. An expression profile analysis of ES cell-derived definitive endodermal cells and Pdx1-expressing cells.  |  Ogaki, S., et al. 2011. BMC Dev Biol. 11: 13. PMID: 21362171
9. Tissue distribution, ontogeny, and chemical induction of aldo-keto reductases in mice.  |  Pratt-Hyatt, M., et al. 2013. Drug Metab Dispos. 41: 1480-7. PMID: 23660342
10. Profiling of embryonic stem cell differentiation.  |  Shiraki, N., et al. 2014. Rev Diabet Stud. 11: 102-14. PMID: 25148369
11. Characterization of aldo-keto reductase 1C subfamily members encoded in two rat genes (akr1c19 and RGD1564865). Relationship to 9-hydroxyprostaglandin dehydrogenase.  |  Satoshi Endo,., et al. 2021. Arch Biochem Biophys. 700: 108755. PMID: 33482148
12. Aldo-ketoreductase 1c19 ablation does not affect insulin secretion in murine islets.  |  Miyachi, Y., et al. 2021. PLoS One. 16: e0260526. PMID: 34843575

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-AKR1C19 Antibody (A-1) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-AKR1C19 Antibody (A-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

AKR1C19 Antibody (A-1) Specifications

Alternate Product Name: AKR1C19

Product Clone Name: A-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 295-316

Epitope Target: AKR1C19

Epitope Species: mouse

Product Reactivity/Detection: AKR1C19

Species Reactivity/Detection: mouse, rat

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for AKR1C19 Antibody (A-1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin