AKAP 79 Antibody (D-9): sc-17772

AKAP 79 Antibody (D-9) is a mouse monoclonal IgG1 kappa light chain antibody that detects AKAP 79 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. AKAP 79 (D-9) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. AKAP 79 protein plays a crucial role in the spatial and temporal regulation of protein kinase A (PKA) signaling, which is essential for various cellular processes, including synaptic plasticity and memory formation. Located primarily in the postsynaptic densities of neurons, AKAP 79 anchors PKA to specific sites, ensuring activation only in response to localized signals. This compartmentalization is vital for maintaining PKA signaling specificity, as unwanted activation of downstream pathways could disrupt normal cellular function. AKAP 79 interacts with other proteins, such as MAP2 and AKAP 150, which also contribute to precise PKA localization, highlighting the importance of these anchoring proteins in neuronal signaling. Anti-AKAP 79 antibody (D-9) enables valuable insights into PKA signaling mechanisms and their implications in neurobiology.

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LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

AKAP 79 Antibody (D-9) References:

1. AKAP79 and the evolution of the AKAP model.  |  Dodge, K. and Scott, JD. 2000. FEBS Lett. 476: 58-61. PMID: 10878251
2. Localization of the cAMP-dependent protein kinase to the postsynaptic densities by A-kinase anchoring proteins. Characterization of AKAP 79.  |  Carr, DW., et al. 1992. J Biol Chem. 267: 16816-23. PMID: 1512224
3. Type II regulatory subunit dimerization determines the subcellular localization of the cAMP-dependent protein kinase.  |  Scott, JD., et al. 1990. J Biol Chem. 265: 21561-6. PMID: 2147685
4. Mechanisms and dynamics of AKAP79/150-orchestrated multi-protein signalling complexes in brain and peripheral nerve.  |  Zhang, J. and Shapiro, MS. 2016. J Physiol. 594: 31-7. PMID: 25653013
5. Molecular basis of AKAP79 regulation by calmodulin.  |  Patel, N., et al. 2017. Nat Commun. 8: 1681. PMID: 29162807
6. CaMKII regulates the depalmitoylation and synaptic removal of the scaffold protein AKAP79/150 to mediate structural long-term depression.  |  Woolfrey, KM., et al. 2018. J Biol Chem. 293: 1551-1567. PMID: 29196604
7. AKAP79 Orchestrates a Cyclic AMP Signalosome Adjacent to Orai1 Ca2+ Channels.  |  Kar, P., et al. 2021. Function (Oxf). 2: zqab036. PMID: 34458850
8. Nuanced Interactions between AKAP79 and STIM1 with Orai1 Ca2+ Channels at Endoplasmic Reticulum-Plasma Membrane Junctions Sustain NFAT Activation.  |  Lin, YP., et al. 2022. Mol Cell Biol. 42: e0017522. PMID: 36317924
9. Association of protein kinase A and protein phosphatase 2B with a common anchoring protein.  |  Coghlan, VM., et al. 1995. Science. 267: 108-11. PMID: 7528941
10. A-kinase anchoring proteins: a key to selective activation of cAMP-responsive events?  |  Coghlan, VM., et al. 1993. Mol Cell Biochem. 127-128: 309-19. PMID: 7935359
11. Cloning and characterization of AKAP 95, a nuclear protein that associates with the regulatory subunit of type II cAMP-dependent protein kinase.  |  Coghlan, VM., et al. 1994. J Biol Chem. 269: 7658-65. PMID: 8125992
12. Cloning and characterization of a novel A-kinase anchoring protein. AKAP 220, association with testicular peroxisomes.  |  Lester, LB., et al. 1996. J Biol Chem. 271: 9460-5. PMID: 8621616

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-AKAP 79 Antibody (D-9) has 6 citations in a variety of scientific publications.

Primary antibodies like Anti-AKAP 79 Antibody (D-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

AKAP 79 Antibody (D-9) Specifications

Alternate Product Name: AKAP 79

Product Clone Name: D-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 181-285

Epitope Target: AKAP 79

Epitope Species: human

Product Reactivity/Detection: AKAP 79

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 6 citations in various scientific publications

Available Conjugates/Forms for AKAP 79 Antibody (D-9): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin