AKAP 220 Antibody (13): sc-135825

AKAP 220 Antibody (13) is a mouse monoclonal IgG1 kappa light chain antibody that detects AKAP 220 protein of mouse and rat origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Anti-AKAP 220 antibody (13) is available as the non-conjugated format. AKAP 220 protein plays a crucial role in the spatial and temporal regulation of signaling pathways by anchoring protein kinase A (PKA) to specific cellular compartments, which is essential for the precise modulation of various physiological processes. This compartmentalization ensures PKA signaling remains restricted to particular areas within the cell, preventing unwanted activation of downstream targets and maintaining cellular homeostasis. AKAP 220 interaction with the regulatory subunit RII of PKA facilitates this localization, allowing for targeted phosphorylation of substrates involved in critical cellular functions. AKAP 220 also interacts with other proteins, such as MAP2 and AKAP 79, which further underscores AKAP 220′s importance in coordinating complex signaling networks. Anti-AKAP 220 antibody (13) enables researchers to explore AKAP 220′s intricate roles in cAMP-responsive signaling events, particularly in peroxisomal functions.

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AKAP 220 Antibody (13) References:

1. Localization of the cAMP-dependent protein kinase to the postsynaptic densities by A-kinase anchoring proteins. Characterization of AKAP 79.  |  Carr, DW., et al. 1992. J Biol Chem. 267: 16816-23. PMID: 1512224
2. Type II regulatory subunit dimerization determines the subcellular localization of the cAMP-dependent protein kinase.  |  Scott, JD., et al. 1990. J Biol Chem. 265: 21561-6. PMID: 2147685
3. Association of protein kinase A and protein phosphatase 2B with a common anchoring protein.  |  Coghlan, VM., et al. 1995. Science. 267: 108-11. PMID: 7528941
4. A-kinase anchoring proteins: a key to selective activation of cAMP-responsive events?  |  Coghlan, VM., et al. 1993. Mol Cell Biochem. 127-128: 309-19. PMID: 7935359
5. Cloning and characterization of AKAP 95, a nuclear protein that associates with the regulatory subunit of type II cAMP-dependent protein kinase.  |  Coghlan, VM., et al. 1994. J Biol Chem. 269: 7658-65. PMID: 8125992
6. Cloning and characterization of a novel A-kinase anchoring protein. AKAP 220, association with testicular peroxisomes.  |  Lester, LB., et al. 1996. J Biol Chem. 271: 9460-5. PMID: 8621616

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-AKAP 220 Antibody (13) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-AKAP 220 Antibody (13) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

AKAP 220 Antibody (13) Specifications

Alternate Product Name: AKAP 220

Product Clone Name: 13

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 11-173

Epitope Target: AKAP 220

Epitope Species: rat

Product Reactivity/Detection: AKAP 220

Species Reactivity/Detection: mouse, rat

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for AKAP 220 Antibody (13): N/A