AIP2 Antibody (A-5): sc-166239
- AIP2 Antibody (A-5) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against amino acids 1-300 mapping at the N-terminus of AIP2 of human origin
- recommended for detection of AIP2 of human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for AIP2 Antibody (A-5) for WB applications. These reagents are now offered in bundles with AIP2 Antibody (A-5) (see ordering information below).
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AIP2 Antibody (A-5) is a mouse monoclonal IgG1 light chain antibody that detects AIP2 in human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). AIP2, a member of the atrophin interacting protein family, plays a crucial role in cellular signaling and protein interactions, particularly in the context of neurodegenerative diseases. AIP2 (A-5) antibody targets a protein primarily located in the cytoplasm and nucleus, where AIP2 is involved in the regulation of gene expression and modulation of protein stability. Multiple WW domains in AIP2 allow interactions with various partner proteins, facilitating the assembly of protein complexes essential for cellular function. AIP2′s structure includes a HECT domain, characteristic of ubiquitin ligases, enabling participation in the ubiquitination process that tags proteins for degradation. This post-translational modification is vital for maintaining cellular homeostasis and regulating protein turnover, making AIP2 an important player in the pathophysiology of diseases such as Huntington′s disease. AIP2 (A-5) monoclonal antibody serves as an invaluable tool for researchers studying these complex interactions and underlying mechanisms of related disorders.
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AIP2 Antibody (A-5) References:
- Interaction of D-lactate dehydrogenase protein 2 (Dld2p) with F-actin: implication for an alternative function of Dld2p. | Hachiya, NS., et al. 2004. Biochem Biophys Res Commun. 319: 78-82. PMID: 15158445
- The AIP2 E3 ligase acts as a novel negative regulator of ABA signaling by promoting ABI3 degradation. | Zhang, X., et al. 2005. Genes Dev. 19: 1532-43. PMID: 15998807
- The HECT-type E3 ubiquitin ligase AIP2 inhibits activation-induced T-cell death by catalyzing EGR2 ubiquitination. | Chen, A., et al. 2009. Mol Cell Biol. 29: 5348-56. PMID: 19651900
- Nedd4-interacting protein 2, a short half-life membrane protein degraded in lysosomes, negatively controls down-regulation of connexin43. | Ohzono, C., et al. 2010. Biol Pharm Bull. 33: 951-7. PMID: 20522958
- Rice APOPTOSIS INHIBITOR5 coupled with two DEAD-box adenosine 5'-triphosphate-dependent RNA helicases regulates tapetum degeneration. | Li, X., et al. 2011. Plant Cell. 23: 1416-34. PMID: 21467577
- WWP2 is an E3 ubiquitin ligase for PTEN. | Maddika, S., et al. 2011. Nat Cell Biol. 13: 728-33. PMID: 21532586
- Functional analyses of an E3 ligase gene AIP2 from wheat in Arabidopsis revealed its roles in seed germination and pre-harvest sprouting. | Gao, DY., et al. 2014. J Integr Plant Biol. 56: 480-91. PMID: 24279988
- RNAi and CRISPR-Cas silencing E3-RING ubiquitin ligase AIP2 enhances soybean seed protein content. | Shen, B., et al. 2022. J Exp Bot. 73: 7285-7297. PMID: 36112496
- Autoimmune Pancreatitis: From Pathogenesis to Treatment. | Nista, EC., et al. 2022. Int J Mol Sci. 23: PMID: 36293522
- Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins. | Wood, JD., et al. 1998. Mol Cell Neurosci. 11: 149-60. PMID: 9647693
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
AIP2 Antibody (A-5) | sc-166239 | 200 µg/ml | $316.00 | |||
AIP2 Antibody (A-5): m-IgG Fc BP-HRP Bundle | sc-540057 | 200 µg Ab; 10 µg BP | $354.00 | |||
AIP2 Antibody (A-5): m-IgG1 BP-HRP Bundle | sc-541877 | 200 µg Ab; 20 µg BP | $354.00 |