AICAR transformylase Antibody (H-3): sc-365402

AICAR transformylase Antibody (H-3) is a mouse monoclonal IgG1 antibody that detects AICAR transformylase in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). AICAR transformylase, also known as ATIC, plays a crucial role in purine biosynthesis by catalyzing the penultimate step in the production of nucleotides, specifically converting AICAR (5-aminoimidazole-4-carboxamide ribonucleotide) into IMP (inosine monophosphate). This enzymatic activity is vital for cellular functions, as nucleotides are essential for DNA and RNA synthesis, energy transfer, and cell signaling. Deficiencies in the ATIC gene can lead to severe metabolic disorders such as AICA-ribosuria, characterized by the accumulation of AICA-riboside in the body, which can result in neurological impairments including mental retardation, epilepsy, and other debilitating symptoms. Anti-AICAR transformylase antibody (H-3) is an invaluable tool for researchers studying purine metabolism and its associated disorders, providing insights into the molecular mechanisms underlying these conditions.

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AICAR transformylase Antibody (H-3) References:

1. Design, synthesis, and biological evaluation of fluoronitrophenyl substituted folate analogues as potential inhibitors of GAR transformylase and AICAR transformylase.  |  Boger, DL., et al. 2000. Bioorg Med Chem Lett. 10: 1471-5. PMID: 10888335
2. Evaluation of the catalytic mechanism of AICAR transformylase by pH-dependent kinetics, mutagenesis, and quantum chemical calculations.  |  Shim, JH., et al. 2001. J Am Chem Soc. 123: 4687-96. PMID: 11457277
3. Design, synthesis, and biological evaluation of simplified alpha-keto heterocycle, trifluoromethyl ketone, and formyl substituted folate analogues as potential inhibitors of GAR transformylase and AICAR transformylase.  |  Marsilje, TH., et al. 2003. Bioorg Med Chem. 11: 4487-501. PMID: 13129585
4. 10-(2-benzoxazolcarbonyl)-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid: a potential inhibitor of GAR transformylase and AICAR transformylase.  |  Marsilje, TH., et al. 2003. Bioorg Med Chem. 11: 4503-9. PMID: 13129586
5. Genetically selected cyclic-peptide inhibitors of AICAR transformylase homodimerization.  |  Tavassoli, A. and Benkovic, SJ. 2005. Angew Chem Int Ed Engl. 44: 2760-2763. PMID: 15830403
6. Targeting tumour proliferation with a small-molecule inhibitor of AICAR transformylase homodimerization.  |  Spurr, IB., et al. 2012. Chembiochem. 13: 1628-34. PMID: 22764122
7. Impact of genetic variants of ATP binding cassette B1, AICAR transformylase/IMP cyclohydrolase, folyl-polyglutamatesynthetase, and methylenetetrahydrofolatereductase on methotrexate toxicity.  |  Sala-Icardo, L., et al. 2017. Reumatol Clin. 13: 318-325. PMID: 27751863
8. Ubiquitin Degradation of the AICAR Transformylase/IMP Cyclohydrolase Ade16 Regulates the Sexual Reproduction of Cryptococcus neoformans.  |  Han, L., et al. 2023. J Fungi (Basel). 9: PMID: 37504688
9. Characterization of AICAR transformylase/IMP cyclohydrolase (ATIC) bifunctional enzyme from Candidatus Liberibacer asiaticus.  |  Lonare, S., et al. 2024. Biochim Biophys Acta Proteins Proteom. 1872: 141015. PMID: 38615986
10. Aminoimidazolecarboxamide ribotide (AICAR)-transformylase of erythrocytes in formiminotransferase deficiency syndrome.  |  Arakawa, T. and Hirono, H. 1966. Tohoku J Exp Med. 88: 161-4. PMID: 5955239

The preferred AICAR transformylase antibody is AICAR transformylase Antibody (F38 P7 H9): sc-53612.