Agmatinase Antibody (G-12): sc-166414
- Agmatinase Antibody (G-12) is a mouse monoclonal IgG1 κ Agmatinase antibody, cited in 2 publications, provided at 200 µg/ml
- raised against amino acids 53-160 mapping within an internal region of Agmatinase of human origin
- Agmatinase Antibody (G-12) is recommended for detection of Agmatinase of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-Agmatinase Antibody (G-12) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Agmatinase Antibody (G-12) for WB applications. These reagents are now offered in bundles with Agmatinase Antibody (G-12) (see ordering information below).
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Agmatinase Antibody (G-12) is a mouse monoclonal IgG1 kappa light chain antibody that detects Agmatinase protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Agmatinase (G-12) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Agmatinase, also known as agmatine ureohydrolase, is crucial for the hydrolysis of agmatine into putresine and urea, playing a significant role in the biosynthesis of polyamines such as spermidine and spermine. These polyamines are essential for cellular functions, including cell growth, differentiation, and proliferation, making Agmatinase a key player in various physiological and pathological processes. Notably, Agmatinase mRNA is predominantly expressed in the human liver and kidney, with additional expression in tissues like skeletal muscle and brain. Expression is notably upregulated during hepatitis B virus infection, indicating a potential role in the disease′s pathophysiology. Human Agmatinase shares approximately 30% identity with bacterial agmatinases and less than 20% with mammalian arginases, with critical residues for manganese binding at the active site being conserved, highlighting evolutionary significance and functional importance in metabolic pathways.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Agmatinase Antibody (G-12) References:
- Cloning of human agmatinase. An alternate path for polyamine synthesis induced in liver by hepatitis B virus. | Mistry, SK., et al. 2002. Am J Physiol Gastrointest Liver Physiol. 282: G375-81. PMID: 11804860
- Cloning and characterization of human agmatinase. | Iyer, RK., et al. 2002. Mol Genet Metab. 75: 209-18. PMID: 11914032
- Polyamines: metabolism and implications in human diseases. | Moinard, C., et al. 2005. Clin Nutr. 24: 184-97. PMID: 15784477
- Inhibitory effect of agmatine on proliferation of tumor cells by modulation of polyamine metabolism. | Wang, JF., et al. 2005. Acta Pharmacol Sin. 26: 616-22. PMID: 15842783
- Mechanisms involved in the antinociception caused by agmatine in mice. | Santos, AR., et al. 2005. Neuropharmacology. 48: 1021-34. PMID: 15857629
- Expression, crystallization and preliminary X-ray crystallographic analysis of human agmatinase. | Kim, KH., et al. 2005. Acta Crystallogr Sect F Struct Biol Cryst Commun. 61: 889-91. PMID: 16511187
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Agmatinase Antibody (G-12) | sc-166414 | 200 µg/ml | $322.00 | |||
Agmatinase Antibody (G-12): m-IgG Fc BP-HRP Bundle | sc-528960 | 200 µg Ab; 10 µg BP | $361.00 | |||
Agmatinase Antibody (G-12): m-IgGκ BP-HRP Bundle | sc-521599 | 200 µg Ab, 40 µg BP | $361.00 | |||
Agmatinase Antibody (G-12): m-IgG1 BP-HRP Bundle | sc-543238 | 200 µg Ab; 20 µg BP | $361.00 | |||
Agmatinase Antibody (G-12) AC | sc-166414 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Agmatinase Antibody (G-12) HRP | sc-166414 HRP | 200 µg/ml | $322.00 | |||
Agmatinase Antibody (G-12) FITC | sc-166414 FITC | 200 µg/ml | $336.00 | |||
Agmatinase Antibody (G-12) PE | sc-166414 PE | 200 µg/ml | $349.00 | |||
Agmatinase Antibody (G-12) Alexa Fluor® 488 | sc-166414 AF488 | 200 µg/ml | $364.00 | |||
Agmatinase Antibody (G-12) Alexa Fluor® 546 | sc-166414 AF546 | 200 µg/ml | $364.00 | |||
Agmatinase Antibody (G-12) Alexa Fluor® 594 | sc-166414 AF594 | 200 µg/ml | $364.00 | |||
Agmatinase Antibody (G-12) Alexa Fluor® 647 | sc-166414 AF647 | 200 µg/ml | $364.00 | |||
Agmatinase Antibody (G-12) Alexa Fluor® 680 | sc-166414 AF680 | 200 µg/ml | $364.00 | |||
Agmatinase Antibody (G-12) Alexa Fluor® 790 | sc-166414 AF790 | 200 µg/ml | $364.00 |