Agmatinase Activators
Agmatinase, an enzyme encoded by the AGMAT gene in humans, plays a pivotal role in the urea cycle and polyamine metabolism by catalyzing the hydrolysis of agmatine to produce urea and putrescine. This enzyme is not only significant for its metabolic functions but also for its participation in cellular signaling pathways that govern cell proliferation, differentiation, and apoptosis. The expression of agmatinase is tightly regulated within the body and can be influenced by a myriad of factors. These factors can induce the expression of agmatinase, thereby altering its activity levels within various tissues and affecting the overall balance of polyamines in the body. Understanding the regulation of agmatinase expression is crucial as it underpins many physiological processes ranging from nitrogen excretion to the modulation of nitric oxide synthesis.
The induction of agmatinase expression can be achieved through the action of specific chemical activators. For instance, compounds like retinoic acid have the potential to upregulate agmatinase expression by interacting with nuclear receptors, which then bind to response elements on the DNA, leading to an increase in gene transcription. Similarly, epigenetic modifiers such as 5-Azacytidine can induce expression by altering the methylation status of the gene's promoter region, thereby enhancing transcriptional activity. Nutritional elements like Vitamin D3 also play a role in the expression of agmatinase by engaging with their respective receptors to stimulate the transcription of target genes. Moreover, oxidative agents such as hydrogen peroxide can increase expression by activating stress response pathways, which include the upregulation of enzymes like agmatinase that are involved in cellular response to oxidative damage. Environmental and dietary components, including polyphenols like resveratrol and curcumin, are also known to upregulate enzyme expression through their capacity to interact with cellular signaling cascades and transcription factors. These chemicals, among others, are key in their capacity to act as activators of gene expression, highlighting the complex interplay between small molecules and genetic regulation within the cell.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid may upregulate agmatinase expression as it binds to retinoic acid receptors, which could lead to transcriptional activation of genes involved in polyamine synthesis during cellular differentiation processes. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
By inhibiting DNA methyltransferase, 5-Azacytidine could lead to the hypomethylation of the agmatinase gene promoter, thus facilitating the recruitment of transcription factors to enhance gene transcription. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Epigallocatechin gallate may stimulate agmatinase expression by interacting with enzymes that control DNA methylation and histone modification, thereby altering gene expression profiles related to polyamine metabolism. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate may prompt an upsurge in agmatinase transcription by inhibiting histone deacetylases, which can result in a more open chromatin structure around the agmatinase gene, facilitating transcriptional activation. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $71.00 $163.00 $296.00 | 2 | |
Vitamin D3 could prompt the upregulation of agmatinase by engaging with the vitamin D receptor, which may bind to vitamin D response elements in the promoter region of the agmatinase gene, triggering increased transcription. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $31.00 $61.00 $95.00 | 28 | |
Hydrogen peroxide may escalate agmatinase expression via activation of oxidative stress response elements within the gene's promoter, leading to the recruitment of transcription factors that enhance gene expression. | ||||||
3-Hydroxybutyric acid | 300-85-6 | sc-231749 sc-231749A sc-231749B | 1 g 5 g 25 g | $71.00 $122.00 $449.00 | ||
3-Hydroxybutyric acid, through its role as an energy substrate during fasting and ketogenic states, could upregulate agmatinase transcription by signaling cellular energy shifts that necessitate adaptations in polyamine synthesis. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol could enhance the transcription of agmatinase by activating sirtuin pathways, which may lead to deacetylation of histones in the vicinity of the agmatinase gene, thus promoting gene expression. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin may upregulate agmatinase expression by inhibiting the activity of transcription factors such as NF-κB, which, when overactive, can repress the transcription of genes involved in the polyamine synthesis pathway. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $34.00 $74.00 $270.00 $114.00 | 34 | |
N-Acetyl-L-cysteine may increase agmatinase expression by providing cysteine for glutathione synthesis, thereby altering the cellular antioxidant capacity and potentially triggering a response that includes the upregulation of detoxifying enzymes such as agmatinase. | ||||||