ADAR2 Antibody (F-9): sc-390995

ADAR2 Antibody (F-9) is a mouse monoclonal IgG1 antibody that detects ADAR2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ADAR2, also known as adenosine deaminase, RNA-specific (RED1), plays a crucial role in RNA editing by converting adenosine to inosine, which is essential for the proper functioning of various proteins, including the glutamate receptor subunit B. This editing process is vital as it can lead to changes in the amino acid sequence of proteins, thereby influencing their function and activity. The ability of ADAR2 to modify its own pre-mRNA and create new splice sites highlights its importance in regulating gene expression and protein diversity. Furthermore, the translocation of endogenous ADAR2 from the nucleolus to the nucleoplasm enhances the editing of its substrates, indicating a dynamic response to cellular conditions. Alternative splicing of the ADAR2 gene results in multiple transcript variants, which may further impact RNA editing efficiency and specificity. With its significant role in post-transcriptional regulation, ADAR2 is a key player in maintaining cellular homeostasis and responding to environmental changes, making anti-ADAR2 antibody (F-9) an invaluable tool for researchers studying RNA editing and its implications in various biological processes.

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ADAR2 Antibody (F-9) References:

1. ADAR2 regulates RNA stability by modifying access of decay-promoting RNA-binding proteins.  |  Anantharaman, A., et al. 2017. Nucleic Acids Res. 45: 4189-4201. PMID: 28053121
2. Cell death cascade and molecular therapy in ADAR2-deficient motor neurons of ALS.  |  Yamashita, T. and Kwak, S. 2019. Neurosci Res. 144: 4-13. PMID: 29944911
3. ADAR2 Is Involved in Self and Nonself Recognition of Borna Disease Virus Genomic RNA in the Nucleus.  |  Yanai, M., et al. 2020. J Virol. 94: PMID: 31852792
4. ADAR2 Regulates Malignant Behaviour of Mesothelioma Cells Independent of RNA-editing Activity.  |  Sakata, KI., et al. 2020. Anticancer Res. 40: 1307-1314. PMID: 32132027
5. The RNA editing enzyme ADAR2 restricts L1 mobility.  |  Frassinelli, L., et al. 2021. RNA Biol. 18: 75-87. PMID: 34224323
6. Lung fibrosis is induced in ADAR2 overexpressing mice via HuR-induced CTGF signaling.  |  Soundararajan, R., et al. 2022. FASEB J. 36: e22143. PMID: 34985777
7. ADAR2 Protein Is Associated with Overall Survival in GBM Patients and Its Decrease Triggers the Anchorage-Independent Cell Growth Signature.  |  Cesarini, V., et al. 2022. Biomolecules. 12: PMID: 36009036
8. Dissecting the basis for differential substrate specificity of ADAR1 and ADAR2.  |  Zambrano-Mila, MS., et al. 2023. Nat Commun. 14: 8212. PMID: 38081817
9. Deficiency of ADAR2 ameliorates metabolic-associated fatty liver disease via AMPK signaling pathways in obese mice.  |  Kung, ML., et al. 2024. Commun Biol. 7: 594. PMID: 38760406
10. RNA editing enzyme ADAR2 regulates P-glycoprotein expression in murine breast cancer cells through the circRNA-miRNA pathway.  |  Omata, Y., et al. 2024. Biochem Biophys Res Commun. 726: 150289. PMID: 38917633

The preferred ADAR2 antibody is ADAR2 Antibody (1.3.1): sc-73409.