ADAR2 Antibody (A-5): sc-393272
- ADAR2 Antibody (A-5) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 281-370 mapping within an internal region of ADAR2 of human origin
- recommended for detection of all ADAR2 isoforms of human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for ADAR2 Antibody (A-5) for WB applications. These reagents are now offered in bundles with ADAR2 Antibody (A-5) (see ordering information below).
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ADAR2 Antibody (A-5) is a mouse monoclonal IgG1 antibody that detects ADAR2 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ADAR2, also known as adenosine deaminase, RNA-specific (RED1), plays a crucial role in RNA editing by converting adenosine to inosine, which is essential for the proper functioning of various proteins, including the glutamate receptor subunit B. This editing process is vital as changes in the amino acid sequence of proteins influence their function and activity. ADAR2′s ability to modify its own pre-mRNA and create new splice sites highlights ADAR2′s importance in regulating gene expression and protein diversity. Furthermore, ADAR2′s translocation from the nucleolus to the nucleoplasm enhances the editing of substrates, indicating a dynamic response to cellular conditions. With alternative splicing resulting in multiple transcript variants, ADAR2′s function is intricately linked to the complexity of RNA processing, making ADAR2 a significant target for research in neurobiology and other fields.
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ADAR2 Antibody (A-5) References:
- ADAR2 editing enzyme is a novel human immunodeficiency virus-1 proviral factor. | Doria, M., et al. 2011. J Gen Virol. 92: 1228-1232. PMID: 21289159
- Unique nuclear vacuoles in the motor neurons of conditional ADAR2-knockout mice. | Sasaki, S., et al. 2014. Brain Res. 1550: 36-46. PMID: 24440630
- A role of ADAR2 and RNA editing of glutamate receptors in mood disorders and schizophrenia. | Kubota-Sakashita, M., et al. 2014. Mol Brain. 7: 5. PMID: 24443933
- Modulation of microRNA editing, expression and processing by ADAR2 deaminase in glioblastoma. | Tomaselli, S., et al. 2015. Genome Biol. 16: 5. PMID: 25582055
- Aberrant alternative splicing pattern of ADAR2 downregulates adenosine-to-inosine editing in glioma. | Li, Z., et al. 2015. Oncol Rep. 33: 2845-52. PMID: 25873329
- Lipopolysaccharide enhances ADAR2 which drives Hirschsprung's disease by impairing miR-142-3p biogenesis. | Peng, L., et al. 2018. J Cell Mol Med. 22: 4045-4055. PMID: 29956457
- ADAR2-mediated Q/R editing of GluK2 regulates kainate receptor upscaling in response to suppression of synaptic activity. | Gurung, S., et al. 2018. J Cell Sci. 131: PMID: 30559217
- Comprehensive interrogation of the ADAR2 deaminase domain for engineering enhanced RNA editing activity and specificity. | Katrekar, D., et al. 2022. Elife. 11: PMID: 35044296
- Targeting the androgen receptor to enhance NK cell killing efficacy in bladder cancer by modulating ADAR2/circ_0001005/PD-L1 signaling. | Liu, Q., et al. 2022. Cancer Gene Ther. 29: 1988-2000. PMID: 35915245
- Heterogeneous RNA editing and influence of ADAR2 on mesothelioma chemoresistance and the tumor microenvironment. | Hariharan, A., et al. 2022. Mol Oncol. 16: 3949-3974. PMID: 36221913
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ADAR2 Antibody (A-5) | sc-393272 | 200 µg/ml | $322.00 | |||
ADAR2 Antibody (A-5): m-IgG Fc BP-HRP Bundle | sc-540894 | 200 µg Ab; 10 µg BP | $361.00 | |||
ADAR2 Antibody (A-5): m-IgG1 BP-HRP Bundle | sc-542446 | 200 µg Ab; 20 µg BP | $361.00 |