ADAR2 Antibody (A-3): sc-393068
- ADAR2 Antibody (A-3) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 681-712 near the C-terminus of ADAR2 of human origin
- recommended for detection of ADAR2 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including porcine
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for ADAR2 Antibody (A-3) for WB applications. These reagents are now offered in bundles with ADAR2 Antibody (A-3) (see ordering information below).
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ADAR2 Antibody (A-3) is a mouse monoclonal IgG1 antibody that detects ADAR2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ADAR2, also known as adenosine deaminase, RNA-specific (RED1), plays a crucial role in RNA editing by converting adenosine to inosine, which is essential for the proper functioning of various proteins, including the glutamate receptor subunit B. This editing process not only alters the amino acid sequence of proteins, potentially affecting their function and interactions, but also allows for the generation of new splice sites, thereby increasing the diversity of the proteome. The ability of ADAR2 to modify its own pre-mRNA highlights a regulatory role in gene expression and the importance of post-transcriptional modifications in cellular processes. Furthermore, ADAR2 translocation from the nucleolus to the nucleoplasm enhances editing activity on endogenous substrates, underscoring the dynamic nature of cellular function. With diverse applications and significant role in RNA editing, anti-ADAR2 antibody (A-3) serves as an invaluable tool for researchers studying gene regulation and protein function.
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ADAR2 Antibody (A-3) References:
- ADAR2-dependent RNA editing of AMPA receptor subunit GluR2 determines vulnerability of neurons in forebrain ischemia. | Peng, PL., et al. 2006. Neuron. 49: 719-33. PMID: 16504947
- Requirement of the RNA-editing enzyme ADAR2 for normal physiology in mice. | Horsch, M., et al. 2011. J Biol Chem. 286: 18614-22. PMID: 21467037
- ADAR2-editing activity inhibits glioblastoma growth through the modulation of the CDC14B/Skp2/p21/p27 axis. | Galeano, F., et al. 2013. Oncogene. 32: 998-1009. PMID: 22525274
- Effect of mismatch on binding of ADAR2/GluR-2 pre-mRNA complex. | Yang, J., et al. 2015. J Mol Model. 21: 222. PMID: 26252972
- Splicing variants of ADAR2 and ADAR2-mediated RNA editing in glioma. | Fu, Y., et al. 2016. Oncol Lett. 12: 788-792. PMID: 27446352
- ADAR2 functions as a tumor suppressor via editing IGFBP7 in esophageal squamous cell carcinoma. | Chen, YB., et al. 2017. Int J Oncol. 50: 622-630. PMID: 28035363
- ADAR2/miR-589-3p axis controls glioblastoma cell migration/invasion. | Cesarini, V., et al. 2018. Nucleic Acids Res. 46: 2045-2059. PMID: 29267965
- ADAR2-dependent A-to-I RNA editing in the extracellular linear and circular RNAs. | Hosaka, T., et al. 2019. Neurosci Res. 147: 48-57. PMID: 30448461
- AKT-Dependent Phosphorylation of ADAR1p110 and ADAR2 Represents a New and Important Link Between Cell Signaling and RNA Editing. | Piazzi, M., et al. 2020. DNA Cell Biol. 39: 343-348. PMID: 31999481
- Exercise-Induced ADAR2 Protects against Nonalcoholic Fatty Liver Disease through miR-34a. | Wang, Z., et al. 2022. Nutrients. 15: PMID: 36615779
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ADAR2 Antibody (A-3) | sc-393068 | 200 µg/ml | $322.00 | |||
ADAR2 Antibody (A-3): m-IgG Fc BP-HRP Bundle | sc-540886 | 200 µg Ab; 10 µg BP | $361.00 | |||
ADAR2 Antibody (A-3): m-IgG1 BP-HRP Bundle | sc-542441 | 200 µg Ab; 20 µg BP | $361.00 | |||
ADAR2 (A-3) Neutralizing Peptide | sc-393068 P | 100 µg/0.5 ml | $69.00 |