ACTL8 Antibody (A-4): sc-377372
- ACTL8 Antibody (A-4) is a mouse monoclonal IgG2b κ ACTL8 antibody, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 339-365 at the C-terminus of ACTL8 of human origin
- ACTL8 Antibody (A-4) is recommended for detection of ACTL8 of human origin by WB, IP, IF and ELISA
- Anti-ACTL8 Antibody (A-4) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgGκ BP-HRP is the preferred secondary detection reagent for ACTL8 Antibody (A-4) for WB applications. This reagent is now offered in a bundle with ACTL8 Antibody (A-4) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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ACTL8 Antibody (A-4) is a mouse monoclonal IgG2b kappa light chain antibody that detects ACTL8 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ACTL8 (A-4) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. ACTL8, also known as actin-like protein 8 or cancer/testis antigen 57, is a member of the actin-related protein family, characterized by an actin fold that plays a crucial role in spindle orientation, nuclear migration, and chromatin remodeling. ACTL8 is primarily localized in the cytoplasm and is notably expressed in the testis and pancreas, where ACTL8 contributes to essential cellular processes. With a length of 366 amino acids, ACTL8 is encoded by a gene located on human chromosome 1, which spans 260 million base pairs and contains over 3,000 genes, accounting for nearly 8% of the human genome. This chromosome is home to numerous disease-associated genes, including those linked to familial adenomatous polyposis, Stickler syndrome, Parkinson′s disease, Gaucher disease, schizophrenia, and Usher syndrome. Aberrations in chromosome 1 are implicated in various cancers, such as head and neck cancer, malignant melanoma, and multiple myeloma, highlighting ACTL8′s relevance in both normal physiology and disease states.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
ACTL8 Antibody (A-4) References:
- Schizophrenia and affective disorders--cosegregation with a translocation at chromosome 1q42 that directly disrupts brain-expressed genes: clinical and P300 findings in a family. | Blackwood, DH., et al. 2001. Am J Hum Genet. 69: 428-33. PMID: 11443544
- New insights into the evolution of chromosome 1. | Weise, A., et al. 2005. Cytogenet Genome Res. 108: 217-22. PMID: 15545733
- Identification of cancer/testis-antigen genes by massively parallel signature sequencing. | Chen, YT., et al. 2005. Proc Natl Acad Sci U S A. 102: 7940-5. PMID: 15905330
- Chromosome 1 abnormalities in multiple myeloma. | Marzin, Y., et al. 2006. Anticancer Res. 26: 953-9. PMID: 16619492
- The DNA sequence and biological annotation of human chromosome 1. | Gregory, SG., et al. 2006. Nature. 441: 315-21. PMID: 16710414
- Association analysis of chromosome 1 migraine candidate genes. | Fernandez, F., et al. 2007. BMC Med Genet. 8: 57. PMID: 17727731
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ACTL8 Antibody (A-4) | sc-377372 | 200 µg/ml | $322.00 | |||
ACTL8 Antibody (A-4): m-IgGκ BP-HRP Bundle | sc-551107 | 200 µg Ab; 40 µg BP | $361.00 | |||
ACTL8 Antibody (A-4) AC | sc-377372 AC | 500 µg/ml, 25% agarose | $424.00 | |||
ACTL8 Antibody (A-4) HRP | sc-377372 HRP | 200 µg/ml | $322.00 | |||
ACTL8 Antibody (A-4) FITC | sc-377372 FITC | 200 µg/ml | $336.00 | |||
ACTL8 Antibody (A-4) PE | sc-377372 PE | 200 µg/ml | $349.00 | |||
ACTL8 Antibody (A-4) Alexa Fluor® 488 | sc-377372 AF488 | 200 µg/ml | $364.00 | |||
ACTL8 Antibody (A-4) Alexa Fluor® 546 | sc-377372 AF546 | 200 µg/ml | $364.00 | |||
ACTL8 Antibody (A-4) Alexa Fluor® 594 | sc-377372 AF594 | 200 µg/ml | $364.00 | |||
ACTL8 Antibody (A-4) Alexa Fluor® 647 | sc-377372 AF647 | 200 µg/ml | $364.00 | |||
ACTL8 Antibody (A-4) Alexa Fluor® 680 | sc-377372 AF680 | 200 µg/ml | $364.00 | |||
ACTL8 Antibody (A-4) Alexa Fluor® 790 | sc-377372 AF790 | 200 µg/ml | $364.00 | |||
ACTL8 (A-4) Neutralizing Peptide | sc-377372 P | 100 µg/0.5 ml | $69.00 |