Acid Ceramidase Antibody (23): sc-136275

Acid Ceramidase Antibody (23) is a mouse monoclonal IgG1 kappa light chain antibody that detects Acid Ceramidase protein of human origin by western blotting (WB) and immunoprecipitation (IP). Anti-Acid Ceramidase antibody (23) is available as a non-conjugated format. Acid Ceramidase (23) antibody recognizes a protein crucial in sphingolipid metabolism by catalyzing ceramide degradation, a bioactive lipid involved in cell signaling, apoptosis, and inflammation. Acid Ceramidase (23) monoclonal antibody targets a protein associated with Farber disease, a genetic disorder where ceramide accumulation due to acid ceramidase deficiency leads to severe joint and neurological issues. Anti-Acid Ceramidase antibody (23) detects a protein identified among the top five genes linked to melanoma, highlighting its significance in cancer biology. Acid Ceramidase (23) monoclonal antibody recognizes a protein with dual functionality, capable of both hydrolyzing ceramide and catalyzing ceramide synthesis under specific pH conditions, demonstrating its importance in maintaining sphingolipid homeostasis and various pathological conditions.

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Acid Ceramidase Antibody (23) References:

1. Overexpression of acid ceramidase protects from tumor necrosis factor-induced cell death.  |  Strelow, A., et al. 2000. J Exp Med. 192: 601-12. PMID: 10974027
2. Interfacial regulation of acid ceramidase activity. Stimulation of ceramide degradation by lysosomal lipids and sphingolipid activator proteins.  |  Linke, T., et al. 2001. J Biol Chem. 276: 5760-8. PMID: 11104761
3. Human acid ceramidase: processing, glycosylation, and lysosomal targeting.  |  Ferlinz, K., et al. 2001. J Biol Chem. 276: 35352-60. PMID: 11451951
4. A bioinformatic approach to the identification of candidate genes for the development of new cancer diagnostics.  |  Musumarra, G., et al. 2003. Biol Chem. 384: 321-7. PMID: 12675527
5. The reverse activity of human acid ceramidase.  |  Okino, N., et al. 2003. J Biol Chem. 278: 29948-53. PMID: 12764132
6. Purification and characterization of recombinant, human acid ceramidase. Catalytic reactions and interactions with acid sphingomyelinase.  |  He, X., et al. 2003. J Biol Chem. 278: 32978-86. PMID: 12815059
7. Elevation of the level and activity of acid ceramidase in Alzheimer's disease brain.  |  Huang, Y., et al. 2004. Eur J Neurosci. 20: 3489-97. PMID: 15610181
8. Acid ceramidase, an emerging target for anti-cancer and anti-angiogenesis.  |  Cho, SM. and Kwon, HJ. 2019. Arch Pharm Res. 42: 232-243. PMID: 30661200
9. Acid Ceramidase: A Novel Therapeutic Target in Cancer.  |  Vijayan, Y., et al. 2019. Curr Top Med Chem. 19: 1512-1520. PMID: 30827244
10. Acid ceramidase regulates innate immune memory.  |  Rother, N., et al. 2023. Cell Rep. 42: 113458. PMID: 37995184
11. Molecular cloning and characterization of a full-length complementary DNA encoding human acid ceramidase. Identification Of the first molecular lesion causing Farber disease.  |  Koch, J., et al. 1996. J Biol Chem. 271: 33110-5. PMID: 8955159
12. Purification, characterization, and biosynthesis of human acid ceramidase.  |  Bernardo, K., et al. 1995. J Biol Chem. 270: 11098-102. PMID: 7744740

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Acid Ceramidase Antibody (23) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-Acid Ceramidase Antibody (23) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Acid Ceramidase Antibody (23) Specifications

Alternate Product Name: ASAH1

Product Clone Name: 23

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 88-182

Epitope Target: Acid Ceramidase α

Epitope Species: human

Product Reactivity/Detection: Acid Ceramidase α

Species Reactivity/Detection: human

Additional Mammalian Reactivity: canine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for Acid Ceramidase Antibody (23): N/A

The preferred Acid Ceramidase antibody is Acid Ceramidase Antibody (F-9): sc-518165.