Aciculin Antibody (F-11): sc-374530

Aciculin Antibody (F-11) is a mouse monoclonal IgG2a antibody that detects Aciculin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Aciculin, also known as PGM5 (phosphoglucomutase 5), is a 567 amino acid protein that plays a crucial role in the interconversion of glucose-1-phosphate and glucose-6-phosphate, which is vital for cellular energy metabolism and glycogen synthesis. Aciculin is predominantly localized at cell junctions and is highly expressed in smooth and cardiac muscle tissues, where Aciculin binds magnesium as a cofactor and interacts with dystrophin and utrophin, suggesting involvement in maintaining cytoskeletal integrity and function. Aciculin exists in two alternatively spliced isoforms and is encoded by a gene located on human chromosome 9, a region that contains over 900 genes and accounts for nearly 4% of the human genome. Aciculin′s ability to interact with key cytoskeletal proteins highlights importance in muscle function and cellular architecture, making anti-Aciculin antibody (F-11) an essential tool for researchers studying muscle physiology and related disorders.

The preferred Aciculin antibody is Aciculin Antibody (14F8): sc-73613.